| Gene Symbol |
CASC5
|
| Entrez Gene |
57082
|
| Alt Symbol |
AF15Q14, CT29, D40, KNL1, PPP1R55, Spc7, hKNL-1, hSpc105
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cancer susceptibility candidate 5
|
| Other Description |
ALL1-fused gene from chromosome 15q14 protein|blinkin, bub-linking kinetochore protein|cancer susceptibility candidate gene 5 protein|cancer/testis antigen 29|kinetochore null 1 homolog|kinetochore-null protein 1|protein CASC5|protein phosphatase 1, regulatory subunit 55
|
| Swissprots |
Q9NR92 Q8NHE1 Q8NG31 Q9HCK2 Q8WXA6
|
| Accessions |
EAW92429 EAW92430 Q8NG31 AB022190 BAC05691 AB046790 BAB13396 AF173994 AAM45143 AF248041 AAF97513 AF461041 AAL67803 AK307605 AK307996 BC014306 BC029373 AAH29373 BC043597 BC172422 AAI72422 BQ776141 U52052 XM_011521816 XP_011520118 XM_011521817 XP_011520119 NM_144508 NP_653091 NM_170589 NP_733468
|
| Function |
Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986}.
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle.
|
| Tissue Specificity |
Highly expressed in testis, where it is localized in germ cells, in particular in spermatocytes and in the pre-acrosome of round spermatids. Detected in the acrosome of ejaculated spermatozoa. Detected in adult thymus, bone marrow, colon, small intestine, appendix and placenta, and in fetal liver and thymus. {ECO:0000269|PubMed:10980622, ECO:0000269|PubMed:12087463, ECO:0000269|PubMed:12618768}.
|