CASC5

Gene Symbol CASC5
Entrez Gene 57082
Alt Symbol AF15Q14, CT29, D40, KNL1, PPP1R55, Spc7, hKNL-1, hSpc105
Species Human
Gene Type protein-coding
Description cancer susceptibility candidate 5
Other Description ALL1-fused gene from chromosome 15q14 protein|blinkin, bub-linking kinetochore protein|cancer susceptibility candidate gene 5 protein|cancer/testis antigen 29|kinetochore null 1 homolog|kinetochore-null protein 1|protein CASC5|protein phosphatase 1, regulatory subunit 55
Swissprots Q9NR92 Q8NHE1 Q8NG31 Q9HCK2 Q8WXA6
Accessions EAW92429 EAW92430 Q8NG31 AB022190 BAC05691 AB046790 BAB13396 AF173994 AAM45143 AF248041 AAF97513 AF461041 AAL67803 AK307605 AK307996 BC014306 BC029373 AAH29373 BC043597 BC172422 AAI72422 BQ776141 U52052 XM_011521816 XP_011520118 XM_011521817 XP_011520119 NM_144508 NP_653091 NM_170589 NP_733468
Function Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:17981135, ECO:0000269|PubMed:18045986}.
Subcellular Location Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle.
Tissue Specificity Highly expressed in testis, where it is localized in germ cells, in particular in spermatocytes and in the pre-acrosome of round spermatids. Detected in the acrosome of ejaculated spermatozoa. Detected in adult thymus, bone marrow, colon, small intestine, appendix and placenta, and in fetal liver and thymus. {ECO:0000269|PubMed:10980622, ECO:0000269|PubMed:12087463, ECO:0000269|PubMed:12618768}.

CASC5 CRISPR/Cas9 KO Plasmid (h) - sc-406138 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CASC5 HDR Plasmid (h) - sc-406138-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CASC5 Double Nickase Plasmid (h) - sc-406138-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CASC5 Double Nickase Plasmid (h2) - sc-406138-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CASC5 CRISPR Activation Plasmid (h) - sc-406138-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CASC5 CRISPR Activation Plasmid (h2) - sc-406138-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CASC5 Lentiviral Activation Particles (h) - sc-406138-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CASC5 Lentiviral Activation Particles (h2) - sc-406138-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CASC5 siRNA (h) - sc-90063 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CASC5 shRNA Plasmid (h) - sc-90063-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CASC5 shRNA (h) Lentiviral Particles - sc-90063-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU097151 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU095521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU134771 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN5379 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5379 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05095 from Sigma-Aldrich

Category miRNA

CASC5 siRNA (Human) - CRJ1308 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CASC5 - MBS8207603 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CASC5(NM_170589.3) - SHG142147 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human CASC5(NM_144508.3) - SHG142165 from Creative biogene

Category siRNA
Species Reactivities Human

Human CASC5 siRNA - orb271809 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CASC5 shRNA Plasmid (Human) - CHJ1308 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CASC5 miRNA 3'UTR clone - MiUTR1H-01677 from Creative biogene

Species Reactivities Human

CASC5 miRNA 3'UTR clone - MiUTR1H-01678 from Creative biogene

Species Reactivities Human
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