CASC5

Gene Symbol	CASC5
Entrez Gene	57082
Alt Symbol	AF15Q14, CT29, D40, KNL1, PPP1R55, Spc7, hKNL-1, hSpc105
Species	Human
Gene Type	protein-coding
Description	cancer susceptibility candidate 5
Other Description	ALL1-fused gene from chromosome 15q14 protein\|blinkin, bub-linking kinetochore protein\|cancer susceptibility candidate gene 5 protein\|cancer/testis antigen 29\|kinetochore null 1 homolog\|kinetochore-null protein 1\|protein CASC5\|protein phosphatase 1, regulatory subunit 55
Swissprots	Q9NR92 Q8NHE1 Q8NG31 Q9HCK2 Q8WXA6
Accessions	EAW92429 EAW92430 Q8NG31 AB022190 BAC05691 AB046790 BAB13396 AF173994 AAM45143 AF248041 AAF97513 AF461041 AAL67803 AK307605 AK307996 BC014306 BC029373 AAH29373 BC043597 BC172422 AAI72422 BQ776141 U52052 XM_011521816 XP_011520118 XM_011521817 XP_011520119 NM_144508 NP_653091 NM_170589 NP_733468
Function	Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269\|PubMed:15502821, ECO:0000269\|PubMed:17981135, ECO:0000269\|PubMed:18045986}.
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Note=Weakly expressed in interphase nuclei. Expression increases from prophase to late anaphase, but greatly diminishes from the telophase and cytokinesis to early G1 phase of cell cycle.
Tissue Specificity	Highly expressed in testis, where it is localized in germ cells, in particular in spermatocytes and in the pre-acrosome of round spermatids. Detected in the acrosome of ejaculated spermatozoa. Detected in adult thymus, bone marrow, colon, small intestine, appendix and placenta, and in fetal liver and thymus. {ECO:0000269\|PubMed:10980622, ECO:0000269\|PubMed:12087463, ECO:0000269\|PubMed:12618768}.

CASC5 (K-14) - sc-242311 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-CASC5 antibody - ab70537 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling CASC5 with ab70537 at 1/1000 (1µg/ml). Detection: DAB.

Anti-CASC5 antibody - ab95127 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ab95127, at 1/250 dilution, staining CASC5 in formalin-fixed, paraffin-embedded Human lung carcinoma by Immunohistochemistry using DAB staining.

Anti-CASC5 antibody - ab199889 from Abcam

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CASC5 antibody (ab199889) at 1/1000 dilutionLane 1 : HeLa total cell extractLane 2 : Jurkat total cell extract

Anti-CASC5 Antibody (aa300-350) - LS-C77820 from LifeSpan Bioscience

Prices	$545.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa250-300) - LS-C77819 from LifeSpan Bioscience

Prices	$605.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa1557-1583, AP) - LS-C253392 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa1557-1583, APC) - LS-C253395 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa1557-1583, FITC) - LS-C253396 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa1557-1583, Azide-free, HRP) - LS-C253398 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa1557-1583, Biotin) - LS-C253397 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa1557-1583, PE) - LS-C253399 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa1556-1583) - LS-C320004 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa250-300) - LS-C287661 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CASC5 Antibody (aa1557-1583) - LS-C158179 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Mouse Casc5 Antibody western blot of mouse kidney tissue lysates (35 ug/lane). The Casc5 antibody detected the Casc5 protein (arrow).

Anti-CASC5 Antibody (aa300-350) - LS-C286715 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human CASC5 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-CASC5 used at a dilution of 1:250. Epitope Retrieval Buffer-High pH (IHC-101J) was substituted for Epitope Retrieval Buffer-Reduced pH.

Anti-CASC5 Antibody (aa300-350) - LS-C287662 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CASC5 Antibody - NB100-2586 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry: CASC5 Antibody [NB100-2586] - Sample: FFPE section of human lung cancer. Antibody: Affinity purified rabbit anti-CASC5 used at a dilution of 1:5,000 (0.2ug/ml). Detection: DAB

CASC5 Antibody - NBP1-89223 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: CASC5 Antibody [NBP1-89223] - Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm.

HSPC105 Antibody - NBP1-92015 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: HSPC105 Antibody [NBP1-92015] - Staining of human skin shows moderate cytoplasmic positivity in melanocytes.

CASC5 Antibody - NB100-2585 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: CASC5 Antibody [NB100-2585] - Detection of Human CASC5 on HeLa whole cell lysate using NB100-2585. CASC5 was also immunoprecipitated by rabbit anti-CASC5 antibody NB100-2586.

CASC5 Polyclonal Antibody - bs-5959R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Paraformaldehyde-fixed, paraffin embedded Mouse testis; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with CASC5 Polyclonal Antibody, Unconjugated (bs-5959R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining.

Anti -CASC5 (CASC-5, Cancer Susceptibility Candidate 5, D40, KIAA1570) - C2082 from USBiological Life Science

Host	Rabbit
Clonality	Polyclonal

Anti -CASC5 (CASC-5, Cancer Susceptibility Candidate 5, D40, KIAA1570) - C2082-01 from USBiological Life Science

Host	Rabbit
Clonality	Polyclonal

CASC5 - MBS611594 from MyBioSource

Prices	$655.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

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