| Gene Symbol |
TECPR1
|
| Entrez Gene |
25851
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tectonin beta-propeller repeat containing 1
|
| Other Description |
tectonin beta-propeller repeat-containing protein 1
|
| Swissprots |
C9J024 A8KAD1 B3KPZ1 Q9P2I9 Q7Z6L1 F5GX57 Q96EB0 Q9UFR6
|
| Accessions |
EAL23891 EAL23892 EAW76716 EAW76717 EAW76718 Q7Z6L1 AB037779 BAA92596 AK027072 AK057048 BAG51853 AK057618 AK075074 AK292996 BAF85685 AL117495 CAB55961 BC012529 AAH12529 BC053591 AAH53591 BE616972 BQ009108 DA336445 XM_005250253 XP_005250310 XR_428174 NM_015395 NP_056210
|
| Function |
Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}.
|
| Subcellular Location |
Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes.
|