Gene Symbol | TECPR1 |
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Entrez Gene | 25851 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | tectonin beta-propeller repeat containing 1 |
Other Description | tectonin beta-propeller repeat-containing protein 1 |
Swissprots | C9J024 A8KAD1 B3KPZ1 Q9P2I9 Q7Z6L1 F5GX57 Q96EB0 Q9UFR6 |
Accessions | EAL23891 EAL23892 EAW76716 EAW76717 EAW76718 Q7Z6L1 AB037779 BAA92596 AK027072 AK057048 BAG51853 AK057618 AK075074 AK292996 BAF85685 AL117495 CAB55961 BC012529 AAH12529 BC053591 AAH53591 BE616972 BQ009108 DA336445 XM_005250253 XP_005250310 XR_428174 NM_015395 NP_056210 |
Function | Tethering factor involved in autophagy. Involved in autophagosome maturation by promoting the autophagosome fusion with lysosomes: acts by associating with both the ATG5-ATG12 conjugate and phosphatidylinositol-3-phosphate (PtdIns(3)P) present at the surface of autophagosomes. Also involved in selective autophagy against bacterial pathogens, by being required for phagophore/preautophagosomal structure biogenesis and maturation. {ECO:0000269|PubMed:21575909, ECO:0000269|PubMed:22342342}. |
Subcellular Location | Cytoplasmic vesicle, autophagosome membrane. Lysosome membrane. Note=Localizes to Lysosome membranes, and binds PtdIns(3)P at the surface of autophagosome. Localizes to autolysosomes, a vesicle formed by the fusion between autophagosomes and lysosomes. |
TECPR1 CRISPR/Cas9 KO Plasmid (h) - sc-409865 from Santa Cruz Biotechnology
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TECPR1 HDR Plasmid (h) - sc-409865-HDR from Santa Cruz Biotechnology
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TECPR1 Double Nickase Plasmid (h) - sc-409865-NIC from Santa Cruz Biotechnology
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TECPR1 Double Nickase Plasmid (h2) - sc-409865-NIC-2 from Santa Cruz Biotechnology
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TECPR1 CRISPR Activation Plasmid (h) - sc-409865-ACT from Santa Cruz Biotechnology
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TECPR1 CRISPR Activation Plasmid (h2) - sc-409865-ACT-2 from Santa Cruz Biotechnology
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TECPR1 Lentiviral Activation Particles (h) - sc-409865-LAC from Santa Cruz Biotechnology
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TECPR1 Lentiviral Activation Particles (h2) - sc-409865-LAC-2 from Santa Cruz Biotechnology
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TECPR1 siRNA (h) - sc-89558 from Santa Cruz Biotechnology
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TECPR1 shRNA Plasmid (h) - sc-89558-SH from Santa Cruz Biotechnology
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TECPR1 shRNA (h) Lentiviral Particles - sc-89558-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU104191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21200 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21200 from Sigma-Aldrich
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TECPR1 siRNA (Human) - CRH8543 from Cohesion Biosciences
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TECPR1 - MBS8239901 from MyBioSource
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shRNA set against Human TECPR1 (NM_015395.1) - SHH425480 from Creative biogene
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shRNA set against Human DKFZP434B0335(NM_015395.1) - SHH005969 from Creative biogene
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TECPR1 shRNA Plasmid (Human) - CHH8543 from Cohesion Biosciences
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TECPR1 miRNA 3'UTR clone - MiUTR1H-02844 from Creative biogene
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