| Gene Symbol |
CACNA1E
|
| Entrez Gene |
777
|
| Alt Symbol |
BII, CACH6, CACNL1A6, Cav2.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, R type, alpha 1E subunit
|
| Other Description |
brain calcium channel II|calcium channel, L type, alpha-1 polypeptide|calcium channel, R type, alpha-1 polypeptide|calcium channel, voltage-dependent, alpha 1E subunit|voltage-dependent R-type calcium channel subunit alpha-1E|voltage-dependent calcium channel alpha 1E subunit|voltage-gated calcium channel alpha 1E subunit|voltage-gated calcium channel alpha subunit Cav2.3|voltage-gated calcium channel subunit alpha Cav2.3
|
| Swissprots |
Q14580 Q15878 B1AM12 Q14581 B1AM14 B1AM13
|
| Accessions |
AAD38389 AAF37687 AAF37688 CAB81554 EAW91103 EAW91104 EAW91105 EAW91106 EAW91107 EAW91108 EAW91109 EAW91110 Q15878 AA349993 AB209499 BAD92736 AK096563 AK309070 AW452628 BC037800 BC172376 AAI72376 BE504178 BI914369 BP230397 CD580303 L27745 AAA72125 L29384 AAA59204 L29385 AAA59205 R11722 XM_011509971 XP_011508273 NM_000721 NP_000712 NM_001205293 NP_001192222 NM_001205294 NP_001192223
|
| Function |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in neuronal tissues and in kidney.
|
| Top Pathways |
Type II diabetes mellitus, MAPK signaling pathway, Calcium signaling pathway
|