CACNA1E
| Gene Symbol | CACNA1E |
|---|---|
| Entrez Gene | 777 |
| Alt Symbol | BII, CACH6, CACNL1A6, Cav2.3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, R type, alpha 1E subunit |
| Other Description | brain calcium channel II|calcium channel, L type, alpha-1 polypeptide|calcium channel, R type, alpha-1 polypeptide|calcium channel, voltage-dependent, alpha 1E subunit|voltage-dependent R-type calcium channel subunit alpha-1E|voltage-dependent calcium channel alpha 1E subunit|voltage-gated calcium channel alpha 1E subunit|voltage-gated calcium channel alpha subunit Cav2.3|voltage-gated calcium channel subunit alpha Cav2.3 |
| Swissprots | Q14580 Q15878 B1AM12 Q14581 B1AM14 B1AM13 |
| Accessions | AAD38389 AAF37687 AAF37688 CAB81554 EAW91103 EAW91104 EAW91105 EAW91106 EAW91107 EAW91108 EAW91109 EAW91110 Q15878 AA349993 AB209499 BAD92736 AK096563 AK309070 AW452628 BC037800 BC172376 AAI72376 BE504178 BI914369 BP230397 CD580303 L27745 AAA72125 L29384 AAA59204 L29385 AAA59205 R11722 XM_011509971 XP_011508273 NM_000721 NP_000712 NM_001205293 NP_001192222 NM_001205294 NP_001192223 |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in neuronal tissues and in kidney. |
| Top Pathways | Type II diabetes mellitus, MAPK signaling pathway, Calcium signaling pathway |
R-type Ca ++ CP α1E CRISPR/Cas9 KO Plasmid (h) - sc-405657 from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E HDR Plasmid (h) - sc-405657-HDR from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E Double Nickase Plasmid (h) - sc-405657-NIC from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E Double Nickase Plasmid (h2) - sc-405657-NIC-2 from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E CRISPR Activation Plasmid (h) - sc-405657-ACT from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E CRISPR Activation Plasmid (h2) - sc-405657-ACT-2 from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E Lentiviral Activation Particles (h) - sc-405657-LAC from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E Lentiviral Activation Particles (h2) - sc-405657-LAC-2 from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E siRNA (h) - sc-42702 from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E shRNA Plasmid (h) - sc-42702-SH from Santa Cruz Biotechnology
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R-type Ca ++ CP α1E shRNA (h) Lentiviral Particles - sc-42702-V from Santa Cruz Biotechnology
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CACNA1E RNAi - H00000777-R01 from Novus Biologicals
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MISSION® esiRNA - EHU079721 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5264 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5264 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11758 from Sigma-Aldrich
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CACNA1E siRNA (Human) - CRH0542 from Cohesion Biosciences
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CACNA1E - MBS8229984 from MyBioSource
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shRNA set against Human CACNA1E (NM_000721.3) - SHH253297 from Creative biogene
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Human CACNA1E siRNA - orb261044 from Biorbyt
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CACNA1E shRNA Plasmid (Human) - CHH0542 from Cohesion Biosciences
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