| Gene Symbol | DRD1 |
|---|---|
| Entrez Gene | 1812 |
| Alt Symbol | DADR, DRD1A |
| Species | Human |
| Gene Type | protein-coding |
| Description | dopamine receptor D1 |
| Other Description | D(1A) dopamine receptor|dopamine D1 receptor |
| Swissprots | Q4QRJ0 P21728 B2RA44 |
| Accessions | AAB26273 BAC05902 CAA39284 CAA39286 EAW61376 EAW61377 P21728 AF498961 AAM18131 AK314031 BAG36741 BC074978 AAH74978 BC074979 AAH74979 BC096837 AAH96837 CR541922 CAG46720 DA249160 X58987 CAA41734 NM_000794 NP_000785 |
| Function | Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
| Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250}. |
| Tissue Specificity | Detected in caudate, nucleus accumbens and in the olfactory tubercle. {ECO:0000269|PubMed:2144334}. |
| Top Pathways | Amphetamine addiction, cAMP signaling pathway, Alcoholism, Cocaine addiction, Morphine addiction |