Gene Symbol | DRD1 |
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Entrez Gene | 1812 |
Alt Symbol | DADR, DRD1A |
Species | Human |
Gene Type | protein-coding |
Description | dopamine receptor D1 |
Other Description | D(1A) dopamine receptor|dopamine D1 receptor |
Swissprots | Q4QRJ0 P21728 B2RA44 |
Accessions | AAB26273 BAC05902 CAA39284 CAA39286 EAW61376 EAW61377 P21728 AF498961 AAM18131 AK314031 BAG36741 BC074978 AAH74978 BC074979 AAH74979 BC096837 AAH96837 CR541922 CAG46720 DA249160 X58987 CAA41734 NM_000794 NP_000785 |
Function | Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase. |
Subcellular Location | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Transport from the endoplasmic reticulum to the cell surface is regulated by interaction with DNAJC14. {ECO:0000250}. |
Tissue Specificity | Detected in caudate, nucleus accumbens and in the olfactory tubercle. {ECO:0000269|PubMed:2144334}. |
Top Pathways | Amphetamine addiction, cAMP signaling pathway, Alcoholism, Cocaine addiction, Morphine addiction |
D1DR CRISPR/Cas9 KO Plasmid (h) - sc-400532 from Santa Cruz Biotechnology
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D1DR HDR Plasmid (h) - sc-400532-HDR from Santa Cruz Biotechnology
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D1DR Double Nickase Plasmid (h) - sc-400532-NIC from Santa Cruz Biotechnology
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D1DR Double Nickase Plasmid (h2) - sc-400532-NIC-2 from Santa Cruz Biotechnology
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D1DR CRISPR Activation Plasmid (h) - sc-400532-ACT from Santa Cruz Biotechnology
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D1DR CRISPR Activation Plasmid (h2) - sc-400532-ACT-2 from Santa Cruz Biotechnology
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D1DR Lentiviral Activation Particles (h) - sc-400532-LAC from Santa Cruz Biotechnology
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D1DR Lentiviral Activation Particles (h2) - sc-400532-LAC-2 from Santa Cruz Biotechnology
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D1DR siRNA (h) - sc-35159 from Santa Cruz Biotechnology
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D1DR shRNA Plasmid (h) - sc-35159-SH from Santa Cruz Biotechnology
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D1DR shRNA (h) Lentiviral Particles - sc-35159-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU000091 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1814 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1814 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07759 from Sigma-Aldrich
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DRD1 siRNA (Human) - CRH1264 from Cohesion Biosciences
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Dopamine D1 R/DRD1 RNAi - H00001812-R02 from Novus Biologicals
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DRD1 - MBS8234774 from MyBioSource
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shRNA set against Human DRD1 (NM_000794.3) - SHH281001 from Creative biogene
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shRNA set against Human DRD1(NM_000794.3) - SHH015581 from Creative biogene
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Human DRD1 siRNA - orb261766 from Biorbyt
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DRD1 shRNA Plasmid (Human) - CHH1264 from Cohesion Biosciences
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DRD1 miRNA 3'UTR clone - MiUTR1H-02993 from Creative biogene
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