| Gene Symbol |
TPRKB
|
| Entrez Gene |
51002
|
| Alt Symbol |
CGI-121
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TP53RK binding protein
|
| Other Description |
EKC/KEOPS complex subunit TPRKB|PRPK (p53-related protein kinase)-binding protein|PRPK-binding protein|TP53RK-binding protein
|
| Swissprots |
Q8IWR7 Q8IWR6 D6W5H6 Q9Y3C4 Q9H3K4
|
| Accessions |
CAJ42830 EAW99720 EAW99721 EAW99722 EAW99723 Q9Y3C4 AF060921 AAG43133 AF151879 AAD34116 AI759966 AK097254 AK291071 BAF83760 AK295239 BAG58232 AY157986 AAN76356 AY157987 AAN76357 AY643713 AAT64915 BC029492 AAH29492 DA688967 XM_005264343 XP_005264400 XM_005264345 XP_005264402 XM_006712026 XP_006712089 XM_006712027 XP_006712090 XM_011532877 XP_011531179 XM_011532878 XP_011531180 XM_011532879 XP_011531181 XM_011532880 XP_011531182 NM_016058 NP_057142
|
| Function |
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TPRKB acts as an allosteric effector that regulates the t(6)A activity of the complex. TPRKB is not required for tRNA modification (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:12659830}.
|