| Gene Symbol |
TSEN54
|
| Entrez Gene |
283989
|
| Alt Symbol |
PCH2A, PCH4, PCH5, SEN54L, sen54
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TSEN54 tRNA splicing endonuclease subunit
|
| Other Description |
SEN54 homolog|hsSen54|tRNA-intron endonuclease Sen54|tRNA-splicing endonuclease subunit Sen54
|
| Swissprots |
Q86WV3 Q7Z6J9 Q8N9H2 Q86XE4
|
| Accessions |
Q7Z6J9 AK094466 BAC04362 AK097583 BAG53490 BC045551 BC047793 AAH47793 BC053643 AAH53643 BE247638 BE251582 BX424294 CV810347 XM_005257229 XP_005257286 XM_006721821 XP_006721884 XM_011524616 XP_011522918 XM_011524617 XP_011522919 XM_011524618 XP_011522920 XR_243646 NM_207346 NP_997229
|
| Function |
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.
|
| Subcellular Location |
Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.
|