TSEN54

Gene Symbol TSEN54
Entrez Gene 283989
Alt Symbol PCH2A, PCH4, PCH5, SEN54L, sen54
Species Human
Gene Type protein-coding
Description TSEN54 tRNA splicing endonuclease subunit
Other Description SEN54 homolog|hsSen54|tRNA-intron endonuclease Sen54|tRNA-splicing endonuclease subunit Sen54
Swissprots Q86WV3 Q7Z6J9 Q8N9H2 Q86XE4
Accessions Q7Z6J9 AK094466 BAC04362 AK097583 BAG53490 BC045551 BC047793 AAH47793 BC053643 AAH53643 BE247638 BE251582 BX424294 CV810347 XM_005257229 XP_005257286 XM_006721821 XP_006721884 XM_011524616 XP_011522918 XM_011524617 XP_011522919 XM_011524618 XP_011522920 XR_243646 NM_207346 NP_997229
Function Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events. {ECO:0000269|PubMed:15109492}.
Subcellular Location Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.

TSEN54-Over-expression-Lysate - LY15571a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag TSEN54 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 2) or transiently transfected with theTSEN54 gene

TSEN54 overexpression lysate - LY403972 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

TSEN54 (h): 293T Lysate - sc-116179 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

TSEN54 Overexpression Lysate (Native) - NBP2-04492 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: TSEN54 Overexpression Lysate (Adult Normal) [NBP2-04492] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TSEN54.

Panoply™ Human TSEN54 Knockdown Stable Cell Line - CSC-DC016708 from Creative biogene

Category Cell Line
Species Human
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