| Gene Symbol |
Acd
|
| Entrez Gene |
497652
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
adrenocortical dysplasia
|
| Other Description |
adrenocortical dysplasia protein
|
| Swissprots |
Q99KF8 Q3V3Y1 Q3TUR7 Q5EE38 Q3TBB1 Q3UKL6
|
| Accessions |
AAW82804 EDL11302 EDL11303 Q5EE38 AK032683 BAE43282 AK052768 AK145959 BAE26785 AK160599 BAE35904 AK170606 AK171345 BAE42403 AK171458 BC004682 AAH04682 BC138694 AAI38695 BC138695 AAI38696 BC145384 XM_006531169 XP_006531232 XM_006531170 XP_006531233 XM_006531174 XP_006531237 XM_006531175 XP_006531238 XM_006531176 XP_006531239 XM_011248435 XP_011246737 XR_878844 NM_001012638 NP_001012656
|
| Function |
Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity (By similarity). Plays a role in shelterin complex assembly. May play an essential role in organogenesis of the developing embryo. {ECO:0000250, ECO:0000269|PubMed:15537664}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:15537664}.
|