Gene Symbol | Acd |
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Entrez Gene | 497652 |
Alt Symbol | - |
Species | Mouse |
Gene Type | protein-coding |
Description | adrenocortical dysplasia |
Other Description | adrenocortical dysplasia protein |
Swissprots | Q99KF8 Q3V3Y1 Q3TUR7 Q5EE38 Q3TBB1 Q3UKL6 |
Accessions | AAW82804 EDL11302 EDL11303 Q5EE38 AK032683 BAE43282 AK052768 AK145959 BAE26785 AK160599 BAE35904 AK170606 AK171345 BAE42403 AK171458 BC004682 AAH04682 BC138694 AAI38695 BC138695 AAI38696 BC145384 XM_006531169 XP_006531232 XM_006531170 XP_006531233 XM_006531174 XP_006531237 XM_006531175 XP_006531238 XM_006531176 XP_006531239 XM_011248435 XP_011246737 XR_878844 NM_001012638 NP_001012656 |
Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity (By similarity). Plays a role in shelterin complex assembly. May play an essential role in organogenesis of the developing embryo. {ECO:0000250, ECO:0000269|PubMed:15537664}. |
Subcellular Location | Nucleus {ECO:0000250}. Chromosome, telomere {ECO:0000305}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15537664}. |
ACD (A-8) - sc-377318 from Santa Cruz Biotechnology
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ACD (M-300) - sc-134659 from Santa Cruz Biotechnology
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Anti-PTOP antibody - ab104297 from Abcam
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ACD Antibody - NBP1-80212 from Novus Biologicals
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Anti-ACD, (C-terminal) antibody produced in rabbit - SAB2105243 from Sigma-Aldrich
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Acd antibody - C-terminal region (ARP36813_P050) - ARP36813_P050 from Aviva Systems Biology
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ACD antibody, C-term - GTX44638 from GeneTex
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Acd antibody - 70R-8190 from Fitzgerald
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ACD (C-term) antibody - AP45068PU-N from Acris Antibodies
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Acd Antibody - GWB-MM472D from Genway Biotech
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Acd-antibody-C-terminal-region-AI11035 - AI11035 from Abgent, a WuXi AppTec company
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ACD (C-term) antibody - TA341742 from Acris Antibodies
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Acd antibody - C-terminal region : Biotin (ARP36813_P050-Biotin) - ARP36813_P050-Biotin from Aviva Systems Biology
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Acd antibody - C-terminal region : FITC (ARP36813_P050-FITC) - ARP36813_P050-FITC from Aviva Systems Biology
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Acd antibody - C-terminal region : HRP (ARP36813_P050-HRP) - ARP36813_P050-HRP from Aviva Systems Biology
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Anti-Acd Antibody A00985 - A00985 from Boster Bio
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Adrenocortical Dysplasia Homolog, Polyclonal Antibody - MBS2032653 from MyBioSource
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