Gene Symbol | NXN |
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Entrez Gene | 64359 |
Alt Symbol | NRX, TRG-4 |
Species | Human |
Gene Type | protein-coding |
Description | nucleoredoxin |
Other Description | nucleoredoxin 1 |
Swissprots | D3DTH2 Q9H9Q1 Q6P3U6 Q3SWW6 Q7L4C6 B4DXQ0 Q6DKJ4 |
Accessions | EAW90639 EAW90640 EAW90641 Q6DKJ4 AF086523 AK022676 BAB14171 AK027451 BAB55122 AK297990 BAG60298 AK302073 BAG63462 AW752727 AY189690 AAO85223 BC009327 AAH09327 BC063828 AAH63828 BC073845 AAH73845 BC104634 AAI04635 BC152722 AAI52723 BC153025 AAI53026 BU856030 CX786695 XM_005256756 XP_005256813 XM_005256757 XP_005256814 XM_005256758 XP_005256815 NM_001205319 NP_001192248 NM_022463 NP_071908 |
Function | Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. |
Nucleoredoxin CRISPR/Cas9 KO Plasmid (h) - sc-413004 from Santa Cruz Biotechnology
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Nucleoredoxin HDR Plasmid (h) - sc-413004-HDR from Santa Cruz Biotechnology
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Nucleoredoxin Double Nickase Plasmid (h) - sc-413004-NIC from Santa Cruz Biotechnology
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Nucleoredoxin Double Nickase Plasmid (h2) - sc-413004-NIC-2 from Santa Cruz Biotechnology
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Nucleoredoxin CRISPR Activation Plasmid (h) - sc-413004-ACT from Santa Cruz Biotechnology
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Nucleoredoxin CRISPR Activation Plasmid (h2) - sc-413004-ACT-2 from Santa Cruz Biotechnology
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Nucleoredoxin Lentiviral Activation Particles (h) - sc-413004-LAC from Santa Cruz Biotechnology
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Nucleoredoxin Lentiviral Activation Particles (h2) - sc-413004-LAC-2 from Santa Cruz Biotechnology
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Nucleoredoxin siRNA (h) - sc-93857 from Santa Cruz Biotechnology
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Nucleoredoxin shRNA Plasmid (h) - sc-93857-SH from Santa Cruz Biotechnology
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Nucleoredoxin shRNA (h) Lentiviral Particles - sc-93857-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU124881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15651 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10299 from Sigma-Aldrich
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NXN siRNA (Human) - CRJ1993 from Cohesion Biosciences
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Nucleoredoxin RNAi - H00064359-R01 from Novus Biologicals
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shRNA set against Human NXN (NM_022463.4) - SHH356756 from Creative biogene
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Human NXN siRNA - orb272494 from Biorbyt
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NXN shRNA Plasmid (Human) - CHJ1993 from Cohesion Biosciences
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NXN miRNA 3'UTR clone - MiUTR3H-12672 from Creative biogene
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