| Gene Symbol |
PARPBP
|
| Entrez Gene |
55010
|
| Alt Symbol |
AROM, C12orf48, PARI
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PARP1 binding protein
|
| Other Description |
PARP-1 binding protein|PARP1-binding protein|PCNA-interacting partner
|
| Swissprots |
Q9NWS1 Q4KMW7 B4E0Y0 Q05C00 Q4FZA0 Q6NSC6 Q86W36 Q499L8 Q6PJA1
|
| Accessions |
EAW97690 EAW97691 EAW97692 Q9NWS1 AA757264 AF274940 AAK07517 AK000648 BAA91306 AK300041 BAG61852 AK302724 BAG63943 AK303571 BAG64592 BC014313 BC018903 AAH18903 BC030962 AAH30962 BC050696 AAH50696 BC070270 AAH70270 BC098297 BC098313 AAH98313 BC099734 AAH99734 BC099844 AAH99844 DB260405 XM_011538506 XP_011536808 XM_011538507 XP_011536809 XM_011538508 XP_011536810 XM_011538509 XP_011536811 XM_011538510 XP_011536812 XM_011538511 XP_011536813 XM_011538512 XP_011536814 XM_011538513 XP_011536815 XM_011538514 XP_011536816 XM_011538515 XP_011536817 XM_011538516 XP_011536818 XM_011538517 XP_011536819 XM_011538518 XP_011536820 XM_011538519 XP_011536821 XM_011538520 XP_011536822 NM_017915 NP_060385
|
| Function |
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect. {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.
|
| Tissue Specificity |
Restricted to testis. Overexpressed in multiple cancer cells. {ECO:0000269|PubMed:20931645}.
|
![Western Blot: C12orf48 Overexpression Lysate (Adult Normal) [NBP2-06899] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for C12orf48.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8349_C12orf48%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06899-img0001.jpg)