PARPBP

Gene Symbol PARPBP
Entrez Gene 55010
Alt Symbol AROM, C12orf48, PARI
Species Human
Gene Type protein-coding
Description PARP1 binding protein
Other Description PARP-1 binding protein|PARP1-binding protein|PCNA-interacting partner
Swissprots Q9NWS1 Q4KMW7 B4E0Y0 Q05C00 Q4FZA0 Q6NSC6 Q86W36 Q499L8 Q6PJA1
Accessions EAW97690 EAW97691 EAW97692 Q9NWS1 AA757264 AF274940 AAK07517 AK000648 BAA91306 AK300041 BAG61852 AK302724 BAG63943 AK303571 BAG64592 BC014313 BC018903 AAH18903 BC030962 AAH30962 BC050696 AAH50696 BC070270 AAH70270 BC098297 BC098313 AAH98313 BC099734 AAH99734 BC099844 AAH99844 DB260405 XM_011538506 XP_011536808 XM_011538507 XP_011536809 XM_011538508 XP_011536810 XM_011538509 XP_011536811 XM_011538510 XP_011536812 XM_011538511 XP_011536813 XM_011538512 XP_011536814 XM_011538513 XP_011536815 XM_011538514 XP_011536816 XM_011538515 XP_011536817 XM_011538516 XP_011536818 XM_011538517 XP_011536819 XM_011538518 XP_011536820 XM_011538519 XP_011536821 XM_011538520 XP_011536822 NM_017915 NP_060385
Function Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect. {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}.
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA.
Tissue Specificity Restricted to testis. Overexpressed in multiple cancer cells. {ECO:0000269|PubMed:20931645}.

C12orf48 (N-15) - sc-245198 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

C12orf48 (Y-18) - sc-245199 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-C12orf48 antibody - C-terminal - ab107308 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab107308 stained HeLa cells.  The cells were 100% methanol fixed (5 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody ab107308 at 5µg/mL overnight at +4°C. The secondary antibody (green) was DyLight® 488 Goat anti-Rabbit IgG (H+L) (ab96899) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PARPBP / C12orf48 Antibody (aa529-558, AP) - LS-C221577 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARPBP / C12orf48 Antibody (aa529-558, APC) - LS-C221578 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARPBP / C12orf48 Antibody (aa529-558, Biotin) - LS-C221579 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARPBP / C12orf48 Antibody (aa529-558, Azide-free, HRP) - LS-C221581 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARPBP / C12orf48 Antibody (aa529-558) - LS-C319922 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARPBP / C12orf48 Antibody (aa529-558, PE) - LS-C221582 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PARPBP / C12orf48 Antibody (aa175-224) - LS-C187386 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PARPBP / C12orf48 antibody Western Blot of Fetal Heart. Antibody dilution: 1 ug/ml.

Anti-PARPBP / C12orf48 Antibody (C-Terminus) - LS-C345186 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of PARPBP Antibody with human HeLa Whole Cell lysate.

Anti-PARPBP / C12orf48 Antibody (aa529-558) - LS-C156953 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
C12orf48 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lymph tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PARPBP / C12orf48 Antibody (aa529-558, FITC) - LS-C221580 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

C12orf48 Antibody - NBP1-93969 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: C12orf48 Antibody [NBP1-93969] - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm.

ANTI-C12ORF48 (C-TERM) antibody produced in rabbit - SAB1303021 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-C12orf48 (C-term): <B>Cat. No. SAB1303021 </B>: C12orf48 Antibody (C-term) western blot analysis in A549 cell line lysates (35 μg/lane).

Anti-PARPBP antibody produced in rabbit - HPA039677 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-C12orf48: <B>Cat. No. HPA039677</B>: Immunohistochemical staining of human cerebellum shows strong nuclear positivity in Purkinje cells.

PARPBP Antibody - C-terminal region (ARP68105_P050) - ARP68105_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PARPBP Antibody - C-terminal region (ARP68106_P050) - ARP68106_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

C12orf48 Antibody - C-terminal region (OAAB00088) - OAAB00088 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

C12orf48-Antibody-C-term - AP10083b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
C12orf48 Antibody (C-term) (Cat. #AP10083b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the C12orf48 antibody detected the FBXO34 protein (arrow).
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