| Gene Symbol |
SUDS3
|
| Entrez Gene |
64426
|
| Alt Symbol |
SAP45, SDS3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
suppressor of defective silencing 3 homolog (S. cerevisiae)
|
| Other Description |
45 kDa Sin3-associated polypeptide|sin3 histone deacetylase corepressor complex component SDS3|sin3A-associated protein, 45kDa|suppressor of defective silencing 3 protein homolog
|
| Swissprots |
Q9H8D2 Q4KMQ5 Q9H7L9 Q8N6H0
|
| Accessions |
EAW98137 EAW98138 EAW98139 EAW98140 EAW98141 Q9H7L9 AA916093 AK023801 BAB14685 AK024460 BAB15750 AK026749 BC030252 AAH30252 BC045728 BC093990 AAH93990 BC098404 AAH98404 BC112000 AAI12001 BX647687 XM_011538671 XP_011536973 XM_011538672 XP_011536974 XM_011538673 XP_011536975 XM_011538674 XP_011536976 XR_944677 NM_022491 NP_071936
|
| Function |
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21239494}.
|
| Tissue Specificity |
Expressed in various cancer cell ines. {ECO:0000269|PubMed:12724404}.
|