Gene Symbol | SUDS3 |
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Entrez Gene | 64426 |
Alt Symbol | SAP45, SDS3 |
Species | Human |
Gene Type | protein-coding |
Description | suppressor of defective silencing 3 homolog (S. cerevisiae) |
Other Description | 45 kDa Sin3-associated polypeptide|sin3 histone deacetylase corepressor complex component SDS3|sin3A-associated protein, 45kDa|suppressor of defective silencing 3 protein homolog |
Swissprots | Q9H8D2 Q4KMQ5 Q9H7L9 Q8N6H0 |
Accessions | EAW98137 EAW98138 EAW98139 EAW98140 EAW98141 Q9H7L9 AA916093 AK023801 BAB14685 AK024460 BAB15750 AK026749 BC030252 AAH30252 BC045728 BC093990 AAH93990 BC098404 AAH98404 BC112000 AAI12001 BX647687 XM_011538671 XP_011536973 XM_011538672 XP_011536974 XM_011538673 XP_011536975 XM_011538674 XP_011536976 XR_944677 NM_022491 NP_071936 |
Function | Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. {ECO:0000269|PubMed:12724404, ECO:0000269|PubMed:21239494}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:21239494}. |
Tissue Specificity | Expressed in various cancer cell ines. {ECO:0000269|PubMed:12724404}. |
SDS3 CRISPR/Cas9 KO Plasmid (h) - sc-413010 from Santa Cruz Biotechnology
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SDS3 HDR Plasmid (h) - sc-413010-HDR from Santa Cruz Biotechnology
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SDS3 Double Nickase Plasmid (h) - sc-413010-NIC from Santa Cruz Biotechnology
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SDS3 Double Nickase Plasmid (h2) - sc-413010-NIC-2 from Santa Cruz Biotechnology
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SDS3 CRISPR Activation Plasmid (h) - sc-413010-ACT from Santa Cruz Biotechnology
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SDS3 CRISPR Activation Plasmid (h2) - sc-413010-ACT-2 from Santa Cruz Biotechnology
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SDS3 Lentiviral Activation Particles (h) - sc-413010-LAC from Santa Cruz Biotechnology
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SDS3 Lentiviral Activation Particles (h2) - sc-413010-LAC-2 from Santa Cruz Biotechnology
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SDS3 siRNA (h) - sc-95959 from Santa Cruz Biotechnology
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SDS3 shRNA Plasmid (h) - sc-95959-SH from Santa Cruz Biotechnology
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SDS3 shRNA (h) Lentiviral Particles - sc-95959-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU110241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20806 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20806 from Sigma-Aldrich
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SUDS3 siRNA (Human) - CRJ2021 from Cohesion Biosciences
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SUDS3 - MBS8224481 from MyBioSource
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shRNA set against Human SUDS3 (NM_022491.2) - SHH420612 from Creative biogene
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Human SUDS3 siRNA - orb272522 from Biorbyt
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SUDS3 shRNA Plasmid (Human) - CHJ2021 from Cohesion Biosciences
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SUDS3 miRNA 3'UTR clone - MiUTR1H-10042 from Creative biogene
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