| Gene Symbol |
GPM6A
|
| Entrez Gene |
2823
|
| Alt Symbol |
GPM6, M6A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glycoprotein M6A
|
| Other Description |
neuronal membrane glycoprotein M6-a
|
| Swissprots |
Q92602 B7Z642 E9PHI5 P51674
|
| Accessions |
EAX04724 EAX04725 P51674 AI609188 AK226176 AK299788 BAH13128 AX772804 CAE06251 BC010461 BC022508 AAH22508 BC022528 AAH22528 BC032904 BC037853 AAH37853 BC044612 AAH44612 BC053954 BI544825 BI546539 BI596896 BI670059 D49958 BAA08712 DA190376 DA196860 DA507772 DA528125 DA621566 DA915764 DC353381 DQ892372 ABM83298 DQ895581 ABM86507 H16369 U45956 AAB16889 XM_006714183 XP_006714246 XM_011531877 XP_011530179 NM_001261447 NP_001248376 NM_001261448 NP_001248377 NM_005277 NP_005268 NM_201591 NP_963885 NM_201592 NP_963886 NR_048571
|
| Function |
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity). {ECO:0000250}.
|