| Gene Symbol |
Gprc6a
|
| Entrez Gene |
210198
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor, family C, group 6, member A
|
| Other Description |
G-protein coupled receptor family C group 6 member A
|
| Swissprots |
Q5DK52 Q5DK51 Q8K4Z6
|
| Accessions |
EDL05066 Q8K4Z6 AY101365 AAM22280 AY735399 AAW68012 AY735400 AAW68013 AY735401 AAW68014 BC108998 AAI08999 XM_011243151 XP_011241453 NM_153071 NP_694711
|
| Function |
Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. {ECO:0000269|PubMed:15576628, ECO:0000269|PubMed:16199532, ECO:0000269|PubMed:19050760, ECO:0000269|PubMed:20947496}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:15816861}; Multi-pass membrane protein {ECO:0000269|PubMed:15816861}.
|
| Tissue Specificity |
Expressed at high level in liver, lung, spleen and heart. Expressed at lower level in kidney, skeletal muscle and brain. Expressed in E7, E11, E15 and E17 embryos. {ECO:0000269|PubMed:15816861, ECO:0000269|PubMed:16199532}.
|