MAFA

Gene Symbol	MAFA
Entrez Gene	389692
Alt Symbol	RIPE3b1, hMafA
Species	Human
Gene Type	protein-coding
Description	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
Other Description	pancreatic beta-cell-specific transcriptional activator|transcription factor MafA|transcription factor RIPE3b1
Swissprots	Q8NHW3
Accessions	AAL89527 BAC20389 BAJ04327 Q8NHW3 BC156443 AAI56444 NM_201589 NP_963883
Function	Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. {ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:12368292, ECO:0000269|PubMed:15665000, ECO:0000269|PubMed:15993959, ECO:0000269|PubMed:18042454, ECO:0000269|PubMed:19143053}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:11416124, ECO:0000269|PubMed:12368292}. Note=Detected in nuclei of pancreas islet beta cells. {ECO:0000250}.
Top Pathways	Type II diabetes mellitus, Maturity onset diabetes of the young

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human MafA peptide - ab28523 from Abcam Category Peptide

Human MafA protein fragment - ab112437 from Abcam Category Protein Source Wheat germ Species Human

MAFA Antibody Blocking Peptide - LS-E3948 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAFA Antibody Blocking Peptide - LS-E13492 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAFA Antibody Blocking Peptide - LS-E13493 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAFA Antibody Blocking Peptide - LS-E17324 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAFA Antibody Blocking Peptide - LS-E17325 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAFA Antibody Blocking Peptide - LS-E10132 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MafA Protein - H00389692-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MAFA-Antibody-C-term-Blocking-Peptide - BP16148b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAFA-Antibody-Center-Blocking-Peptide - BP9440c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAFA - H00389692-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAFA - H00389692-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Recombinant Human MAFA - MAFA-28859TH from Creative Biomart Category Protein Source Wheat germ Species Human

Recombinant Human Transcription factor MafA(MAFA) - CSB-YP818821HU CSB-EP818821HU CSB-BP818821HU CSB-MP818821HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAFA-Antibody-C-term-Blocking-Peptide - BP9440b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAFA Peptide, Human - M34GP09072H from Creative Peptides Category Peptide Source Synthetic. Species Human

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