MAFA

Gene Symbol MAFA
Entrez Gene 389692
Alt Symbol RIPE3b1, hMafA
Species Human
Gene Type protein-coding
Description v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A
Other Description pancreatic beta-cell-specific transcriptional activator|transcription factor MafA|transcription factor RIPE3b1
Swissprots Q8NHW3
Accessions AAL89527 BAC20389 BAJ04327 Q8NHW3 BC156443 AAI56444 NM_201589 NP_963883
Function Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. {ECO:0000269|PubMed:12011435, ECO:0000269|PubMed:12368292, ECO:0000269|PubMed:15665000, ECO:0000269|PubMed:15993959, ECO:0000269|PubMed:18042454, ECO:0000269|PubMed:19143053}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978, ECO:0000269|PubMed:11416124, ECO:0000269|PubMed:12368292}. Note=Detected in nuclei of pancreas islet beta cells. {ECO:0000250}.
Top Pathways Type II diabetes mellitus, Maturity onset diabetes of the young

MafA CRISPR/Cas9 KO Plasmid (h) - sc-401480 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA HDR Plasmid (h) - sc-401480-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA Double Nickase Plasmid (h) - sc-401480-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA Double Nickase Plasmid (h2) - sc-401480-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA CRISPR Activation Plasmid (h) - sc-401480-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA CRISPR Activation Plasmid (h2) - sc-401480-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA Lentiviral Activation Particles (h) - sc-401480-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA Lentiviral Activation Particles (h2) - sc-401480-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA siRNA (h) - sc-43905 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MafA shRNA Plasmid (h) - sc-43905-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MafA shRNA (h) Lentiviral Particles - sc-43905-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN12902 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MAFA siRNA (Human) - CRJ7899 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MafA RNAi - H00389692-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MafA CRISPR/Cas9 KO Plasmid (h2) - sc-401480-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MafA HDR Plasmid (h2) - sc-401480-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human MafA (NM_201589.3) - SHH336627 from Creative biogene

Category siRNA
Species Reactivities Human

MAFA shRNA Plasmid (Human) - CHJ7899 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAFA miRNA 3'UTR clone - MiUTR4H-TG05268 from Creative biogene

Species Reactivities Human
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