MAP2K4

Gene Symbol	MAP2K4
Entrez Gene	6416
Alt Symbol	JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase 4
Other Description	JNK-activated kinase 1|JNK-activating kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|MAPKK 4|MEK 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4|stress-activated protein kinase kinase 1
Swissprots	Q6FHX4 Q5U0B8 P45985 B2R7N7 Q6PIE6 D3DTS5 Q6P9H2 B3KYB2
Accessions	AAC24130 AAY22176 EAW89973 EAW89974 EAW89975 EAW89976 P45985 AA293365 AK122997 AK131544 BAG54774 AK294923 BAG58005 AK313053 BAG35884 AK316100 BAH14471 AK316177 BAH14548 AU150695 BC036032 AAH36032 BC050386 BC060764 AAH60764 BQ028457 BT019676 AAV38482 CR536564 CAG38801 L31902 L36870 AAC41719 U17743 AAC50127 XM_005256753 XP_005256810 XM_005256755 XP_005256812 XM_011523976 XP_011522278 XM_011523977 XP_011522279 XR_934080 NM_001281435 NP_001268364 NM_003010 NP_003001
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/J
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity	Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Top Pathways	TNF signaling pathway, Toll-like receptor signaling pathway, Epstein-Barr virus infection, Influenza A, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MEK4 full length protein - ab159495 from Abcam Category Protein Source Wheat germ Species Human

Human MEK4 protein fragment - ab159496 from Abcam Category Protein Source Wheat germ Species Human

MAP2K4 / MKK4 Antibody Blocking Peptide - LS-E3716 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP2K4 / MKK4 Antibody Blocking Peptide - LS-E9367 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MKK4/MEK4 Protein - H00006416-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MKK4/MEK4 Recombinant Protein - H00006416-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MKK4/MEK4 Peptide - P2899 from Novus Biologicals Category Peptide Species Human

MEK4-MAP2K4-Antibody-S257-Blocking-peptide - BP7916d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAP2K4 peptide - orb217917 from Biorbyt Category Peptide Prices $357.00, $723.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Zebrafish

SEK1 Blocking Peptide - 33R-10965 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

Human MAP2K4 Protein - abx068037 from Abbexa Category Protein Source E.coli Species Human

MKK4 (phospho-Ser80) Blocking Peptide - abx063248 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Zebrafish

MKK4 (phospho-Thr261) Blocking Peptide - abx063249 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Zebrafish

MKK4 Blocking Peptide - abx063250 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Zebrafish

MAP2K4 - H00006416-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MAP2K4 - H00006416-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MAP2K4 - H00006416-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAP2K4 - H00006416-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAP2K4 - P5585 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

Mitogen Activated Protein Kinase Kinase 4 (MAP2K4), Human - 20-8818 from ARP American Research Products Category Protein Prices $485.00 Sizes 50 µg Source E.coli Species Human

MAP2K4 fusion protein - Ag11348 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

MAP2K4 fusion protein - Ag11376 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SEK1/MKK4 (Phospho-Ser80) Antibody Blocking Peptide - GWB-100352 from Genway Biotech Category Peptide Prices $184.00 Sizes 100 µg

SEK1/MKK4 (Phospho-Thr261) Antibody Blocking Peptide - GWB-3E26DA from Genway Biotech Category Peptide Prices $138.00 Sizes 100 µg

Recombinant Human MAP2K4, His-tagged - MAP2K4-105H from Creative Biomart Category Protein Source Baculovirus infected Sf9 Species Human

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