MAP2K4

Gene Symbol	MAP2K4
Entrez Gene	6416
Alt Symbol	JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1, SKK1
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase 4
Other Description	JNK-activated kinase 1|JNK-activating kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|MAPKK 4|MEK 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4|stress-activated protein kinase kinase 1
Swissprots	Q6FHX4 Q5U0B8 P45985 B2R7N7 Q6PIE6 D3DTS5 Q6P9H2 B3KYB2
Accessions	AAC24130 AAY22176 EAW89973 EAW89974 EAW89975 EAW89976 P45985 AA293365 AK122997 AK131544 BAG54774 AK294923 BAG58005 AK313053 BAG35884 AK316100 BAH14471 AK316177 BAH14548 AU150695 BC036032 AAH36032 BC050386 BC060764 AAH60764 BQ028457 BT019676 AAV38482 CR536564 CAG38801 L31902 L36870 AAC41719 U17743 AAC50127 XM_005256753 XP_005256810 XM_005256755 XP_005256812 XM_011523976 XP_011522278 XM_011523977 XP_011522279 XR_934080 NM_001281435 NP_001268364 NM_003010 NP_003001
Function	Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/J
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Tissue Specificity	Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
Top Pathways	TNF signaling pathway, Toll-like receptor signaling pathway, Epstein-Barr virus infection, Influenza A, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MEK-4 CRISPR/Cas9 KO Plasmid (h) - sc-401459 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-4 HDR Plasmid (h) - sc-401459-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-4 Double Nickase Plasmid (h) - sc-401459-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-4 Double Nickase Plasmid (h2) - sc-401459-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-4 CRISPR Activation Plasmid (h) - sc-401459-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-4 CRISPR Activation Plasmid (h2) - sc-401459-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-4 Lentiviral Activation Particles (h) - sc-401459-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-4 Lentiviral Activation Particles (h2) - sc-401459-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MEK-4 siRNA (h) - sc-35909 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MEK-4 shRNA Plasmid (h) - sc-35909-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MEK-4 shRNA (h) Lentiviral Particles - sc-35909-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU108421 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1107 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1105 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1106 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2132 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2132 from Sigma-Aldrich Category ZFN Kit

MISSION® 3′UTR Lenti GoClone™ - HUTR11470 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr11470

MAP2K4 siRNA (Human) - CRH4333 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

MKK4/MEK4 RNAi - H00006416-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human MAP2K4 (NM_003010.2) - SHH337563 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MAP2K4(NM_003010.2) - SHH173549 from Creative biogene Category siRNA Species Reactivities Human

MAP2K4 shRNA Plasmid (Human) - CHH4333 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

MAP2K4 miRNA 3'UTR clone - MiUTR1H-06055 from Creative biogene Species Reactivities Human

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