ILF3

Gene Symbol ILF3
Entrez Gene 3609
Alt Symbol CBTF, DRBF, DRBP76, MMP4, MPHOSPH4, MPP4, NF-AT-90, NF110, NF110b, NF90, NF90a, NF90b, NFAR, NFAR-1, NFAR2, TCP110, TCP80
Species Human
Gene Type protein-coding
Description interleukin enhancer binding factor 3, 90kDa
Other Description M-phase phosphoprotein 4|double-stranded RNA-binding protein, 76 kD|dsRNA binding protein NFAR-2/MPP4|interleukin enhancer binding factor 3, 90kD|interleukin enhancer-binding factor 3|nuclear factor associated with dsRNA|nuclear factor of activated T-cells 90 kDa|nuclear factor of activated T-cells, 90 kD|translational control protein 80
Swissprots Q9NRN2 Q9NQ98 Q9NQ99 A8K6F2 Q9NQA0 Q9NQA2 G5E9M5 Q9NRN4 Q9NQA1 Q9UMZ9 Q9BZH4 Q9NRN3 Q9NQ95 Q9BZH5 Q9UNA2 Q9NQ96 O43409 Q9UN84 Q9UN00 Q6P1X1 Q99544 Q99545 Q12906 Q9NQ97 Q86XY7
Accessions AAF82685 AAF82686 AAF82687 AAK07424 AAK07425 CAC01121 CAC01122 CAC01123 CAC01124 EAW84131 EAW84132 EAW84133 EAW84134 EAW84135 EAW84136 EAW84137 Q12906 AB209062 BAD92299 AF007140 AAC19152 AF141870 AAD37575 AF147209 AAD33966 AF167569 AAD51098 AF167570 AAD51099 AJ271744 CAC01404 AJ271745 CAC01405 AJ271746 CAC01406 AK000018 BAA90887 AK023222 AK025821 BAB15245 AK291205 BAF83894 AK291617 BAF84306 AK293170 BAG56714 AK294084 BAG57425 AL832528 AW576353 AY240961 AAP68989 BC001770 BC003086 BC014221 BC018633 BC048314 AAH48314 BC064836 AAH64836 BM973331 CR457223 CAG33504 DC320902 HQ322263 AEE02018 HQ322264 AEE02019 HQ322265 AEE02020 U10324 AAA20994 X98264 CAA66917 X98265 CAA66918 XM_005259895 XP_005259952 XM_006722742 XP_006722805 XM_011527984 XP_011526286 XM_011527985 XP_011526287 XM_011527986 XP_011526288 XM_011527987 XP_011526289 NM_001137673 NP_001131145 NM_004516 NP_004507 NM_012218 NP_036350 NM_017620 NP_060090 NM_153464 NP_703194
Function May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N- methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity). {ECO:0000250}.
Subcellular Location Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Tissue Specificity Ubiquitous.

NF90 (A-3) - sc-377406 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NF90 (A-3): sc-377406. Western blot analysis of NF90 expression in HeLa whole cell lysate.

NF90 (H-84) - sc-292884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NF90 (H-84): sc-292884. Western blot analysis of NF90 expression in Jurkat (A) and Hep G2 (B) whole cell lysates.

NF90 (U-21) - sc-102035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
NF90 (U-21): sc-102035. Western blot analysis of NF90 expression in Jurkat nuclear extract.

NF90 (21) - sc-136197 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
NF90 (21): sc-136197. Immunofluorescence staining of WI-38 cells showing nuclear localization.

Anti-ILF3 antibody - ab89100 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-ILF3 antibody (ab89100) at 1 µg/ml + Human pancreas lysate at 50 µg

Anti-ILF3 antibody - ab131004 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ILF3 antibody (ab131004) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-ILF3 antibody - ab58737 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ILF3 antibody (ab58737) at 1 µg/mlLane 1 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate Lane 2 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

Anti-ILF3 antibody [EPR3626] - ab92355 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3626
ILF3 was immunoprecipitated using 0.5mg K562 whole cell extract, 5µg of Rabbit monoclonal to ILF3 and 50µl of protein G magnetic beads (+). No antibody was added to the control (-).The antibody was incubated under agitation with Protein G beads for 10min, K562 whole cell extract lysate diluted in RIPA buffer was added to each sample and incubated for a further 10min under agitation.Proteins were eluted by addition of 40µl SDS loading buffer and incubated for 10min at 70°C; 10µl of each sample was separated on a SDS PAGE gel, transferred to a nitrocellulose membrane, blocked with 5% BSA and probed with ab92355.Secondary: Mouse monoclonal [SB62a] Secondary Antibody to Rabbit IgG light chain (HRP) (ab99697).Band: 95kDa; ILF3

Anti-ILF3 antibody [EPR3627] - ab133354 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3627
All lanes : Anti-ILF3 antibody [EPR3627] (ab133354) at 1/2000 dilutionLane 1 : HeLa cell lysateLane 2 : K562 cell lysateLane 3 : A431 cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-NF90 / ILF3 Antibody (N-Terminus) - LS-C46919 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody (aa1-50) - LS-C286150 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody (C-Terminus) - LS-C31449 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-NF90 / ILF3 Antibody (aa50-100) - LS-C289820 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody (aa456-506) - LS-C289821 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody (aa325-375) - LS-C289822 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody - LS-C308484 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody (aa652-702) - LS-C290312 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody - LS-C311281 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody (aa361-406) - LS-C313852 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody (aa756-805) - LS-C80017 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-NF90 / ILF3 Antibody (aa731-780) - LS-C134939 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ILF3 antibody LS-C134939 Western blot of Mouse Small Intestine lysate.

Anti-NF90 / ILF3 Antibody - LS-C341230 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NF90 / ILF3 Antibody (aa41-90) - LS-C30315 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ILF3 antibody LS-C30315 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.

Anti-NF90 / ILF3 Antibody (Internal, clone EPR3626) - LS-C105588 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR3626
IHC of paraffin-embedded human kidney tissue using anti-ILF3 antibody (LS-C105588).

Anti-NF90 / ILF3 Antibody (aa23-72) - LS-C30453 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ILF3 antibody LS-C30453 was used in IHC to stain formalin-fixed, paraffin-embedded human muscle.
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