| Gene Symbol |
PSMA3
|
| Entrez Gene |
5684
|
| Alt Symbol |
HC8, PSC3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteasome (prosome, macropain) subunit, alpha type, 3
|
| Other Description |
macropain subunit C8|multicatalytic endopeptidase complex subunit C8|proteasome component C8|proteasome subunit C8|proteasome subunit alpha type-3
|
| Swissprots |
Q9BS70 P25788 Q86U83 B2RCK6 Q8N1D8
|
| Accessions |
EAW80715 EAW80716 EAW80717 EAW80718 EAW80719 EAW80720 EAW80721 EAW80722 P25788 AK315158 BAG37603 BC005265 AAH05265 BC029402 AAH29402 BC038990 AAH38990 BG703488 BT006711 AAP35357 BT019715 AAV38520 CF128376 CR456933 CAG33214 D00762 BAA00659 DB520127 DQ892645 ABM83571 DQ895883 ABM86809 NM_002788 NP_002779 NM_152132 NP_687033 NR_038123
|
| Function |
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:17499743}.
|
| Subcellular Location |
Cytoplasm. Nucleus.
|
| Top Pathways |
Proteasome
|