Gene Symbol | PSMA3 |
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Entrez Gene | 5684 |
Alt Symbol | HC8, PSC3 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) subunit, alpha type, 3 |
Other Description | macropain subunit C8|multicatalytic endopeptidase complex subunit C8|proteasome component C8|proteasome subunit C8|proteasome subunit alpha type-3 |
Swissprots | Q9BS70 P25788 Q86U83 B2RCK6 Q8N1D8 |
Accessions | EAW80715 EAW80716 EAW80717 EAW80718 EAW80719 EAW80720 EAW80721 EAW80722 P25788 AK315158 BAG37603 BC005265 AAH05265 BC029402 AAH29402 BC038990 AAH38990 BG703488 BT006711 AAP35357 BT019715 AAV38520 CF128376 CR456933 CAG33214 D00762 BAA00659 DB520127 DQ892645 ABM83571 DQ895883 ABM86809 NM_002788 NP_002779 NM_152132 NP_687033 NR_038123 |
Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:17499743}. |
Subcellular Location | Cytoplasm. Nucleus. |
Top Pathways | Proteasome |
20S Proteasome α3 CRISPR/Cas9 KO Plasmid (h) - sc-401857 from Santa Cruz Biotechnology
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20S Proteasome α3 HDR Plasmid (h) - sc-401857-HDR from Santa Cruz Biotechnology
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20S Proteasome α3 Double Nickase Plasmid (h) - sc-401857-NIC from Santa Cruz Biotechnology
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20S Proteasome α3 Double Nickase Plasmid (h2) - sc-401857-NIC-2 from Santa Cruz Biotechnology
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20S Proteasome α3 CRISPR Activation Plasmid (h) - sc-401857-ACT from Santa Cruz Biotechnology
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20S Proteasome α3 CRISPR Activation Plasmid (h2) - sc-401857-ACT-2 from Santa Cruz Biotechnology
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20S Proteasome α3 Lentiviral Activation Particles (h) - sc-401857-LAC from Santa Cruz Biotechnology
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20S Proteasome α3 Lentiviral Activation Particles (h2) - sc-401857-LAC-2 from Santa Cruz Biotechnology
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20S Proteasome α3 siRNA (h) - sc-62878 from Santa Cruz Biotechnology
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20S Proteasome α3 shRNA Plasmid (h) - sc-62878-SH from Santa Cruz Biotechnology
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20S Proteasome α3 shRNA (h) Lentiviral Particles - sc-62878-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU020951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17590 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17590 from Sigma-Aldrich
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PSMA3 siRNA (Human) - CRH3831 from Cohesion Biosciences
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shRNA set against Human PSMA3 (NM_002788.3) - SHH385064 from Creative biogene
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Human PSMA3 siRNA - orb264333 from Biorbyt
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PSMA3 shRNA Plasmid (Human) - CHH3831 from Cohesion Biosciences
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PSMA3 miRNA 3'UTR clone - MiUTR3H-01864 from Creative biogene
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PSMA3 miRNA 3'UTR clone - MiUTR3H-01865 from Creative biogene
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