Gene Symbol | PSMA3 |
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Entrez Gene | 5684 |
Alt Symbol | HC8, PSC3 |
Species | Human |
Gene Type | protein-coding |
Description | proteasome (prosome, macropain) subunit, alpha type, 3 |
Other Description | macropain subunit C8|multicatalytic endopeptidase complex subunit C8|proteasome component C8|proteasome subunit C8|proteasome subunit alpha type-3 |
Swissprots | Q9BS70 P25788 Q86U83 B2RCK6 Q8N1D8 |
Accessions | EAW80715 EAW80716 EAW80717 EAW80718 EAW80719 EAW80720 EAW80721 EAW80722 P25788 AK315158 BAG37603 BC005265 AAH05265 BC029402 AAH29402 BC038990 AAH38990 BG703488 BT006711 AAP35357 BT019715 AAV38520 CF128376 CR456933 CAG33214 D00762 BAA00659 DB520127 DQ892645 ABM83571 DQ895883 ABM86809 NM_002788 NP_002779 NM_152132 NP_687033 NR_038123 |
Function | The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:17499743}. |
Subcellular Location | Cytoplasm. Nucleus. |
Top Pathways | Proteasome |
Human Proteasome 20S alpha 3 full length protein - ab115712 from Abcam
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Human Proteasome 20S alpha 3 full length protein - ab88125 from Abcam
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PSMA3 Antibody Blocking Peptide - LS-E21092 from LifeSpan Bioscience
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PSMA3 Antibody Blocking Peptide - LS-E21091 from LifeSpan Bioscience
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Proteasome 20S alpha 3 Recombinant Protein - H00005684-P01 from Novus Biologicals
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Proteasome 20S alpha 3 Protein - NBP1-72526 from Novus Biologicals
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Human PSMA3 protein (His Tag) - orb139536 from Biorbyt
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Human PSMA3 protein - orb169088 from Biorbyt
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PSMA3 Blocking Peptide - 33R-9616 from Fitzgerald
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PSMA3 Blocking Peptide - 33R-8998 from Fitzgerald
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PSMA3 (1-255, His-tag) - AR50112PU-N from Acris Antibodies
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PSMA3 (1-255, His-tag) - AR50112PU-S from Acris Antibodies
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PSMA3 - H00005684-P01-10 from Acris Antibodies
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PSMA3 - H00005684-P01-25 from Acris Antibodies
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PSMA3, 1-255 aa, Human, His tag E.coli - 01-2011-3 from ARP American Research Products
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PSMA3 fusion protein - Ag2495 from Proteintech Group
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PSMA3 Human - ENPS-203 from NeoScientific
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Recombinant Human Proteasome Subunit Alpha Type 3 Enzyme - BP002727-ENZ-196 from Syd Labs
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PSMA3, 1-255 aa, Recombinant Protein - GWB-P0751J from Genway Biotech
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Recombinant Human Proteasome (Prosome, Macropain) Subunit, Alpha Type, 3, His-tagged - PSMA3-1287H from Creative Biomart
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Recombinant Human PSMA3, GST-tagged - PSMA3-2011H from Creative Biomart
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Recombinant Human PSMA3, His-tagged - PSMA3-375H from Creative Biomart
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PSMA3 1-255 aa - CMB-1120 from Reagent Proteins
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Human PSMA3 / Proteasome 20S alpha 3 Protein (His Tag) - 15297-H07E-20 from Sino Biological
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Recombinant Human Proteasome subunit alpha type-3(PSMA3) - CSB-YP018867HU CSB-EP018867HU CSB-BP018867HU CSB-MP018867HU from Cusabio
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