Gene Symbol | EFNA4 |
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Entrez Gene | 1945 |
Alt Symbol | EFL4, EPLG4, LERK4 |
Species | Human |
Gene Type | protein-coding |
Description | ephrin-A4 |
Other Description | LERK-4|eph-related receptor tyrosine kinase ligand 4|ligand of eph-related kinase 4 |
Swissprots | C9JHJ8 Q6FI57 O95457 Q5SR71 G3XAK2 P52798 |
Accessions | CAC48189 EAW53138 EAW53139 EAW53140 P52798 AI459151 AI625552 AJ006352 CAA06992 AJ006353 CAA06993 BC042610 BC107483 AAI07484 BE780161 BM740848 BM747625 BQ940212 CD671399 CR533569 CAG38600 U14188 AAC50079 NM_005227 NP_005218 NM_182689 NP_872631 NM_182690 NP_872632 |
Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. |
Subcellular Location | Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. |
Tissue Specificity | Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines. |
Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |
ephrin-A4 (P-20) - sc-914 from Santa Cruz Biotechnology
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ephrin-A4 (H-67) - sc-20721 from Santa Cruz Biotechnology
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Anti-Ephrin A4 antibody - ab53062 from Abcam
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Anti-Ephrin A4 antibody - ab28385 from Abcam
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Anti-Ephrin A4 antibody - ab7041 from Abcam
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Anti-Ephrin A4 antibody [MM0263-9H13] - ab89473 from Abcam
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Anti-Ephrin A4 antibody, prediluted - ab28386 from Abcam
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Anti-EFNA4 / Ephrin A4 Antibody (aa131-180) IHC-plus⢠- LS-B9245 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (C-Terminus) - LS-C6538 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody - LS-C188981 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (Internal, AP) - LS-C213661 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (Internal, APC) - LS-C213662 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (Internal, Biotin) - LS-C213663 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (Internal, FITC) - LS-C213664 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (Internal, Azide-free, HRP) - LS-C213665 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (Internal, PE) - LS-C213666 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (aa63-112) - LS-C145408 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (aa1-206, Biotin) - LS-C298342 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (aa1-204, Biotin) - LS-C298343 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (aa1-204, FITC) - LS-C304864 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (aa1-204, Biotin) - LS-C298347 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (Internal) - LS-C321033 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (aa1-206, FITC) - LS-C304863 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (aa1-204, FITC) - LS-C304865 from LifeSpan Bioscience
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Anti-EFNA4 / Ephrin A4 Antibody (aa1-204) - LS-C293767 from LifeSpan Bioscience
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