EFNA4
| Gene Symbol | EFNA4 |
|---|---|
| Entrez Gene | 1945 |
| Alt Symbol | EFL4, EPLG4, LERK4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ephrin-A4 |
| Other Description | LERK-4|eph-related receptor tyrosine kinase ligand 4|ligand of eph-related kinase 4 |
| Swissprots | C9JHJ8 Q6FI57 O95457 Q5SR71 G3XAK2 P52798 |
| Accessions | CAC48189 EAW53138 EAW53139 EAW53140 P52798 AI459151 AI625552 AJ006352 CAA06992 AJ006353 CAA06993 BC042610 BC107483 AAI07484 BE780161 BM740848 BM747625 BQ940212 CD671399 CR533569 CAG38600 U14188 AAC50079 NM_005227 NP_005218 NM_182689 NP_872631 NM_182690 NP_872632 |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. |
| Subcellular Location | Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. |
| Tissue Specificity | Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines. |
| Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |
ephrin-A4 CRISPR/Cas9 KO Plasmid (h) - sc-404603 from Santa Cruz Biotechnology
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ephrin-A4 HDR Plasmid (h) - sc-404603-HDR from Santa Cruz Biotechnology
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ephrin-A4 Double Nickase Plasmid (h) - sc-404603-NIC from Santa Cruz Biotechnology
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ephrin-A4 Double Nickase Plasmid (h2) - sc-404603-NIC-2 from Santa Cruz Biotechnology
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ephrin-A4 CRISPR Activation Plasmid (h) - sc-404603-ACT from Santa Cruz Biotechnology
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ephrin-A4 CRISPR Activation Plasmid (h2) - sc-404603-ACT-2 from Santa Cruz Biotechnology
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ephrin-A4 Lentiviral Activation Particles (h) - sc-404603-LAC from Santa Cruz Biotechnology
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ephrin-A4 Lentiviral Activation Particles (h2) - sc-404603-LAC-2 from Santa Cruz Biotechnology
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ephrin-A4 siRNA (h) - sc-39432 from Santa Cruz Biotechnology
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ephrin-A4 shRNA Plasmid (h) - sc-39432-SH from Santa Cruz Biotechnology
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ephrin-A4 shRNA (h) Lentiviral Particles - sc-39432-V from Santa Cruz Biotechnology
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Ephrin-A4 RNAi - H00001945-R10 from Novus Biologicals
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MISSION® esiRNA - EHU007751 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7697 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7697 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04101 from Sigma-Aldrich
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EFNA4 siRNA (Human) - CRH1342 from Cohesion Biosciences
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Ephrin-A4 RNAi - H00001945-R12 from Novus Biologicals
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Ephrin-A4 RNAi - H00001945-R11 from Novus Biologicals
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EFNA4 - MBS8211732 from MyBioSource
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shRNA set against Human EFNA4 (NM_182690.2) - SHH283657 from Creative biogene
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shRNA set against Human EFNA4(NM_182689.1) - SHH025769 from Creative biogene
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shRNA set against Human EFNA4(NM_005227.2) - SHH025805 from Creative biogene
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shRNA set against Human EFNA4(NM_182690.2) - SHH025823 from Creative biogene
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Human EFNA4 siRNA - orb261844 from Biorbyt
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