| Gene Symbol | EFNA4 |
|---|---|
| Entrez Gene | 1945 |
| Alt Symbol | EFL4, EPLG4, LERK4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ephrin-A4 |
| Other Description | LERK-4|eph-related receptor tyrosine kinase ligand 4|ligand of eph-related kinase 4 |
| Swissprots | C9JHJ8 Q6FI57 O95457 Q5SR71 G3XAK2 P52798 |
| Accessions | CAC48189 EAW53138 EAW53139 EAW53140 P52798 AI459151 AI625552 AJ006352 CAA06992 AJ006353 CAA06993 BC042610 BC107483 AAI07484 BE780161 BM740848 BM747625 BQ940212 CD671399 CR533569 CAG38600 U14188 AAC50079 NM_005227 NP_005218 NM_182689 NP_872631 NM_182690 NP_872632 |
| Function | Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils. |
| Subcellular Location | Isoform 1: Cell membrane; Lipid-anchor, GPI- anchor. |
| Tissue Specificity | Expressed in the adult spleen, lymph node, prostate, ovary, small intestine, and colon, and in fetal heart, lung, liver and kidney. Also detected in hematopoietic cell lines. |
| Top Pathways | Axon guidance, PI3K-Akt signaling pathway, Rap1 signaling pathway |