| Gene Symbol | CALR |
|---|---|
| Entrez Gene | 811 |
| Alt Symbol | CRT, HEL-S-99n, RO, SSA, cC1qR |
| Species | Human |
| Gene Type | protein-coding |
| Description | calreticulin |
| Other Description | CRP55|ERp60|HACBP|Sicca syndrome antigen A (autoantigen Ro; calreticulin)|calregulin|endoplasmic reticulum resident protein 60|epididymis secretory sperm binding protein Li 99n|grp60 |
| Swissprots | Q9UDG2 Q6IAT4 P27797 |
| Accessions | AAB51176 CAK18761 CCD35250 CRH09108 EAW84330 EAW84331 EAW84332 P27797 AB451408 BAG70222 AF087986 AK130190 AK223060 BAD96780 AK295230 BAG58223 AK304492 BAG65301 AY047586 AAL13126 BC002500 AAH02500 BC007911 AAH07911 BC020493 AAH20493 BC107102 BT007448 AAP36116 CR457070 CAG33351 FJ224311 ACI46003 M32294 AAA36582 M84739 AAA51916 NM_004343 NP_004334 |
| Function | Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum lumen. Cytoplasm, cytosol. Secreted, extracellular space, extracellular matrix. Cell surface. Sarcoplasmic reticulum lumen {ECO:0000250}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes. |
| Top Pathways | Chagas disease (American trypanosomiasis), Phagosome, Protein processing in endoplasmic reticulum, HTLV-I infection, Antigen processing and presentation |