Gene Symbol | BPGM |
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Entrez Gene | 669 |
Alt Symbol | DPGM |
Species | Human |
Gene Type | protein-coding |
Description | 2,3-bisphosphoglycerate mutase |
Other Description | 2,3-bisphosphoglycerate mutase, erythrocyte|2,3-bisphosphoglycerate synthase|2,3-diphosphoglycerate mutase|BPG-dependent PGAM|bisphosphoglycerate mutase|erythrocyte 2,3-bisphosphoglycerate mutase |
Swissprots | A4D1N9 P07738 |
Accessions | AAA51840 CBX85738 CBX85919 EAL24067 EAW83821 EAW83822 EAW83823 EAW83824 P07738 AB209044 BAD92281 AK097778 BAG53525 AK315439 BAG37827 BC017050 AAH17050 BM090687 BU608668 BU664387 BX473275 CB994648 CF242942 DA701935 DB047822 DB049554 HQ447339 ADQ31825 X04327 CAA27858 XM_011516527 XP_011514829 NM_001293085 NP_001280014 NM_001724 NP_001715 NM_199186 NP_954655 |
Function | Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. |
Tissue Specificity | Expressed in red blood cells. Expressed in non-erythroid cells of the placenta; present in the syncytiotrophoblast layer of the placental villi at the feto- maternal interface (at protein level). {ECO:0000269|PubMed:16246416, ECO:0000269|PubMed:3023066, ECO:0000269|PubMed:6313356}. |
Top Pathways | Glycolysis / Gluconeogenesis, Glycine, serine and threonine metabolism |
BPGM CRISPR/Cas9 KO Plasmid (h) - sc-405810 from Santa Cruz Biotechnology
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BPGM HDR Plasmid (h) - sc-405810-HDR from Santa Cruz Biotechnology
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BPGM Double Nickase Plasmid (h) - sc-405810-NIC from Santa Cruz Biotechnology
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BPGM Double Nickase Plasmid (h2) - sc-405810-NIC-2 from Santa Cruz Biotechnology
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BPGM CRISPR Activation Plasmid (h) - sc-405810-ACT from Santa Cruz Biotechnology
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BPGM CRISPR Activation Plasmid (h2) - sc-405810-ACT-2 from Santa Cruz Biotechnology
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BPGM Lentiviral Activation Particles (h) - sc-405810-LAC from Santa Cruz Biotechnology
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BPGM Lentiviral Activation Particles (h2) - sc-405810-LAC-2 from Santa Cruz Biotechnology
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BPGM siRNA (h) - sc-72656 from Santa Cruz Biotechnology
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BPGM shRNA Plasmid (h) - sc-72656-SH from Santa Cruz Biotechnology
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BPGM shRNA (h) Lentiviral Particles - sc-72656-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU077671 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0042 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0041 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0040 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0923 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN4035 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4035 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12330 from Sigma-Aldrich
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BPGM siRNA (Human) - CRH0464 from Cohesion Biosciences
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BPGM - MBS8235108 from MyBioSource
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Human BPGM siRNA - orb260966 from Biorbyt
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BPGM shRNA Plasmid (Human) - CHH0464 from Cohesion Biosciences
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