| Gene Symbol |
DCAF7
|
| Entrez Gene |
10238
|
| Alt Symbol |
AN11, HAN11, SWAN-1, WDR68
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DDB1 and CUL4 associated factor 7
|
| Other Description |
DDB1- and CUL4-associated factor 7|WD repeat-containing protein 68|WD repeat-containing protein An11 homolog|human anthocyanin|seven-WD-repeat protein of the AN11 family-1
|
| Swissprots |
D3DU14 P61962 B4E039
|
| Accessions |
EAW94305 EAW94306 P61962 AA206721 AA634196 AI580937 AK022145 AK025925 AK026008 AK130672 AK294925 BAG58007 AK303212 BAG64301 AL832440 BC001264 AAH01264 BC024682 BC027489 BE889428 BF058090 BF507629 BG684075 BG819062 BM272287 BM559804 BM673647 BQ221019 BQ435051 BX648608 CB162675 CD245570 DA230140 DQ891233 ABM82159 DQ894417 ABM85343 HY023965 U94747 AAC18913 NM_005828 NP_005819 NR_073585 NM_001003725
|
| Function |
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4- DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250, ECO:0000269|PubMed:16887337, ECO:0000269|PubMed:16949367}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
|