BIN1

Gene Symbol BIN1
Entrez Gene 274
Alt Symbol AMPH2, AMPHL, SH3P9
Species Human
Gene Type protein-coding
Description bridging integrator 1
Other Description amphiphysin II|amphiphysin-like protein|box dependant MYC interacting protein 1|box-dependent myc-interacting protein 1|myc box-dependent-interacting protein 1
Swissprots O75516 O00499 O60554 O60553 O75514 Q99688 O00545 O60552 O75518 O75515 O75517 O43867 Q659B7 O60555 Q92944 O00297
Accessions AAC23440 AAC23441 AAY24328 EAW95286 EAW95287 EAW95288 EAW95289 EAW95290 EAW95291 EAW95292 EAW95293 EAW95294 EAW95295 EAW95296 EAW95297 EAW95298 EAW95299 EAW95300 EAW95301 EAW95302 EAW95303 EAW95304 EAW95305 EAW95306 EAW95307 O00499 AF001383 AAB61363 AF004015 AAC51345 AF043898 AAC39710 AF043899 AAC39711 AF043900 AAC39712 AF043901 AAC39713 AF068914 AAC24126 AF068915 AAC24127 AF068916 AAC24128 AF068917 AAC23750 AF068918 AAC23751 AF070576 AAC28646 AK127325 AK295300 BAH12028 AK301153 BAH13418 AL713697 CAD28496 AM392950 CAL37828 BC004101 AAH04101 BM711160 BT006865 AAP35511 CF594020 EU831833 ACE86592 U68485 AAC17461 U87558 AAB63263 XM_005263642 XP_005263699 XM_005263643 XP_005263700 XM_005263644 XP_005263701 XM_005263645 XP_005263702 XM_005263646 XP_005263703 XM_005263647 XP_005263704 XM_005263648 XP_005263705 XM_006712425 XP_006712488 XM_006712426 XP_006712489 XM_006712427 XP_006712490 XM_006712428 XP_006712491 XM_006712429 XP_006712492 XM_006712430 XP_006712493 XM_006712431 XP_006712494 XM_006712432 XP_006712495 XM_006712433 XP_006712496 XM_006712434 XP_006712497 XM_011510975 XP_011509277 NM_004305 NP_004296 NM_139343 NP_647593 NM_139344 NP_647594 NM_139345 NP_647595 NM_139346 NP_647596 NM_139347 NP_647597 NM_139348 NP_647598 NM_139349 NP_647599 NM_139350 NP_647600 NM_139351 NP_647601
Function May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
Subcellular Location Isoform BIN1: Nucleus.
Tissue Specificity Ubiquitous. Highest expression in the brain and muscle. Isoform IIA is expressed only in the brain where it is concentrated in axon initial segments and nodes of Ranvier. Isoform BIN1 is widely expressed with highest expression in skeletal muscle. {ECO:0000269|PubMed:10903846}.

BIN1 Antibody - 13679 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using BIN1 Antibody.

Amphiphysin II (2F11) - sc-23918 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Amphiphysin II (2F11): sc-23918. Western blot analysis of Amphiphysin II and BIN1 splice variant of Amphiphysin II expression in IMR-32 (A) and HeLa (B) whole cell lysates.

Amphiphysin II (D-3) - sc-74486 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Amphiphysin II (D-3): sc-74486. Western blot analysis of Amphiphysin II expression in HeLa nuclear extract (A), Jurkat (B) and SJRH30 (C) whole cell lysates and rat skeletal muscle tissue extract (D).

Amphiphysin II (G-10) - sc-74487 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Amphiphysin II (G-10): sc-74487. Western blot analysis of Amphiphysin II expression in HeLa nuclear extract (A), Jurkat (B) and SJRH30 (C) whole cell lysates and rat skeletal muscle tissue extract (D).

Amphiphysin II (H-100) - sc-30099 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Amphiphysin II (H-100): sc-30099. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Amphiphysin II (N-19) - sc-8534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Amphiphysin II (N-19): sc-8534. Western blot analysis of Amphiphysin II expression in IMR-32 (A) and H4 (B) whole cell lysates.

Amphiphysin II (99D) - sc-13575 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Amphiphysin II (99D): sc-13575. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung tumor showing nuclear and cytoplasmic staining.

Anti-BIN1 antibody - ab113544 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-BIN1 antibody (ab113544) at 1 µg/ml + Skeletal Muscle (Human) Tissue Lysate - adult normal tissue (ab29330) at 10 µgSecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilution

Anti-BIN1 antibody - ab153912 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-BIN1 antibody (ab153912) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-BIN1 antibody - ab137459 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BIN1 antibody (ab137459) at 1/1000 dilutionLane 1 : MOLT4 whole cell lysateLane 2 : Raji whole cell lysateLysates/proteins at 30 µg per lane.

Anti-BIN1 antibody - ab186156 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-BIN1 antibody - ab27796 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-BIN1 antibody (ab27796) at 2 µg/mlLane 1 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899)Lane 2 : Jurkat cells treated with camptothecin for 6 hours

Anti-BIN1 antibody - ab54764 from Abcam

Prices $384.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
ICC/IF image of ab54764 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab54764, 10µg/ml) overnight at +4°C. The secondary antibody (green) was ab96879, DyLight® 488 goat anti-mouse IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-BIN1 antibody - ab123390 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-BIN1 antibody (ab123390) at 1/100 dilution + L929 cell line lysates at 35 µg

Anti-BIN1 antibody - ab106937 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-BIN1 antibody (ab106937) at 0.1 µg/ml + Human skeletal muscle lysate (in RIPA buffer) at 35 µgdeveloped using the ECL technique

Anti-BIN1 antibody - ab115943 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-BIN1 antibody (ab115943) at 1 µg/ml + Mouse pancreas lysate at 10 µg

Anti-BIN1 antibody - ab125444 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-BIN1 antibody (ab125444) at 1 µg/ml + Mouse pancreas lysate at 10 µg

Anti-BIN1 antibody [2F11] - ab84974 from Abcam

Prices $372.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 2F11

Anti-BIN1 antibody [99D] - ab10532 from Abcam

Prices $391.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 99D
Anti-BIN1 antibody [99D] (ab10532) at 1/200000 dilution + Rat brain cytosol extractSecondaryGoat anti-Mouse Fab-specific IgG alkaline phosphatase conjugated antibody

Anti-BIN1 antibody [99D] - ab181710 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 99D
Flow Cytometry analysis of C2C12 cells labeling BIN1 with ab181710 and control (Anti-IgD) antibody. Secondary antibody: Biotin mouse secondary antibody at 1/10,000 for 45 min at RT and streptavidin PE at 1/5,000 for 30 min at RT.

Anti-BIN1 antibody [BN-1] - ab95022 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BN-1
All lanes : Anti-BIN1 antibody [BN-1] (ab95022) at 0.25 µg/mlLane 1 : Rat brain tissue lysateLane 2 : Rat skeletal muscle tissue lysateLane 3 : Rat heart tissue lysateLane 4 : Rat kidney tissue lysate

Anti-BIN1 antibody [EPR13463] - ab182562 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13463
Immunoprecipitation. ab182562 at 1/10000 staining BIN1 in U87-MG cell lysate immunoprecipitated using ab182562 at 1/50.Lane 2: negative control.

Anti-BIN1 antibody [EPR13463-25] - ab185950 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR13463-25
All lanes : Anti-BIN1 antibody [EPR13463-25] (ab185950) at 1/1000 dilutionLane 1 : U87-MG cell lysateLane 2 : Human fetal kidney lysateLane 3 : Hela cell lysateLane 4 : Human fetal brain lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

BIN1 Antibody - NBP2-15587 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: BIN1 Antibody [NBP2-15587] - Sample (50 ug of whole cell lysate) A: Mouse Kidney, 7. 5% SDS PAGE gel, diluted at 1:500.

BIN1 Antibody (99F) - NBP2-21674 from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 99F
Immunocytochemistry/Immunofluorescence: BIN1 Antibody (99F) [NBP2-21674] - Cells: C2C12 cells during growth or differentiation. Fixation: 0.5% PFA. Antigen retrieval: not required. Primary antibody: BIN-1 (Exon 10 specific, 99F) monoclonal antibody. Secondary antibody: mouse secondary antibody at 1:10,000 for 45 min at RT. Localization: BIN1 is nuclear and cytoplasmic. Staining: BIN 1 as green fluorescent signal.
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