| Gene Symbol | LIN7B |
|---|---|
| Entrez Gene | 64130 |
| Alt Symbol | LIN-7B, MALS-2, MALS2, VELI2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | lin-7 homolog B (C. elegans) |
| Other Description | hLin7B|hVeli2|mammalian lin-seven protein 2|protein lin-7 homolog B|veli-2|vertebrate lin-7 homolog 2 |
| Swissprots | Q9HAP6 |
| Accessions | EAW52454 EAW52455 Q9HAP6 AF311862 AAG34117 AY358744 AAQ89104 BC027618 AAH27618 BM069859 XM_005259149 XP_005259206 XM_006723323 XP_006723386 XR_243950 NM_001308419 NP_001295348 NM_022165 NP_071448 |
| Function | Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}. |
Veli2 CRISPR/Cas9 KO Plasmid (h) - sc-412987 from Santa Cruz Biotechnology
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Veli2 HDR Plasmid (h) - sc-412987-HDR from Santa Cruz Biotechnology
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Veli2 Double Nickase Plasmid (h) - sc-412987-NIC from Santa Cruz Biotechnology
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Veli2 Double Nickase Plasmid (h2) - sc-412987-NIC-2 from Santa Cruz Biotechnology
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Veli2 CRISPR Activation Plasmid (h) - sc-412987-ACT from Santa Cruz Biotechnology
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Veli2 CRISPR Activation Plasmid (h2) - sc-412987-ACT-2 from Santa Cruz Biotechnology
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Veli2 Lentiviral Activation Particles (h) - sc-412987-LAC from Santa Cruz Biotechnology
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Veli2 Lentiviral Activation Particles (h2) - sc-412987-LAC-2 from Santa Cruz Biotechnology
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Veli2 siRNA (h) - sc-42318 from Santa Cruz Biotechnology
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Veli2 shRNA Plasmid (h) - sc-42318-SH from Santa Cruz Biotechnology
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Veli2 shRNA (h) Lentiviral Particles - sc-42318-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU050921 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11734 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11734 from Sigma-Aldrich
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LIN7B siRNA (Human) - CRJ1938 from Cohesion Biosciences
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shRNA set against Human LIN7B (NM_022165.2) - SHH330539 from Creative biogene
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shRNA set against Human LIN7B(NM_022165.2) - SHH150581 from Creative biogene
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Human LIN7B siRNA - orb272439 from Biorbyt
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LIN7B shRNA Plasmid (Human) - CHJ1938 from Cohesion Biosciences
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LIN7B miRNA 3'UTR clone - MiUTR1H-05693 from Creative biogene
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