LIN7B

Gene Symbol LIN7B
Entrez Gene 64130
Alt Symbol LIN-7B, MALS-2, MALS2, VELI2
Species Human
Gene Type protein-coding
Description lin-7 homolog B (C. elegans)
Other Description hLin7B|hVeli2|mammalian lin-seven protein 2|protein lin-7 homolog B|veli-2|vertebrate lin-7 homolog 2
Swissprots Q9HAP6
Accessions EAW52454 EAW52455 Q9HAP6 AF311862 AAG34117 AY358744 AAQ89104 BC027618 AAH27618 BM069859 XM_005259149 XP_005259206 XM_006723323 XP_006723386 XR_243950 NM_001308419 NP_001295348 NM_022165 NP_071448
Function Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells. {ECO:0000250}.

Veli2 (A-20) - sc-11502 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Veli2 (Y-19) - sc-11503 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-LIN7B antibody [1C1] - ab117923 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C1
All lanes : Anti-LIN7B antibody [1C1] (ab117923) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY controlLane 2 : HEK293T cells transfected with pCMV6-ENTRY LIN7B cDNA Lysates/proteins at 5 µg per lane.

Anti-LIN7B antibody - N-terminal - ab156073 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-LIN7B antibody - N-terminal (ab156073) at 1/100 dilution + CEM cell line lysates at 35 µg

Anti-LIN7B Antibody (aa2-15) - LS-C55061 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-LIN7B Antibody (aa35-62, AP) - LS-C261937 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LIN7B Antibody (aa35-62, APC) - LS-C261938 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LIN7B Antibody (aa35-62, Biotin) - LS-C261939 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LIN7B Antibody (aa35-62, FITC) - LS-C261940 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LIN7B Antibody (aa35-62, Azide-free, HRP) - LS-C261941 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LIN7B Antibody (aa35-62, PE) - LS-C261942 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LIN7B Antibody (aa35-62) - LS-C322670 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-LIN7B Antibody (clone 1G2) - LS-C115482 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LIN7B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LIN7B.

Anti-LIN7B Antibody (aa35-62) - LS-C157865 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
LIN7B Antibody western blot of mouse cerebellum tissue lysates (35 ug/lane). The LIN7B antibody detected the LIN7B protein (arrow).

Anti-LIN7B Antibody (clone 1F11) - LS-C115455 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1F11
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LIN7B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-LIN7B.

Anti-LIN7B Antibody (clone 1D12) - LS-C172357 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D12
Anti-LIN7B mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY LIN7B.

Anti-LIN7B Antibody (clone 1C9) - LS-C115485 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C9
IHC of paraffin-embedded Human lymph node tissue using anti-LIN7B mouse monoclonal antibody. (Dilution 1:50).

LIN7B Antibody (1C9) - NBP2-02852 from Novus Biologicals

Prices $379.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1C9

LIN7B Antibody - NBP2-19358 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: LIN7B Antibody [NBP2-19358] - Sample (30 ug of whole cell lysate) A: 293T 12% SDS PAGE gel, diluted at 1:1000.

Anti-LIN7B antibody produced in rabbit - HPA046419 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-LIN7B: <B>Cat. No. HPA046419</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells.

Anti-LIN7B (N-terminal) antibody produced in goat - SAB2501891 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-LIN7B (N-terminal): <B>Cat. No. SAB2501891</B>: (0.5 μg/mL) staining of Rat Brain lysate (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-LIN7B (192-205) antibody produced in rabbit - SAB1102402 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human LIN7B was separated on SDS-PAGE, blotted with Anti-LIN7B (192-205) (<B>Cat. No. SAB1102402</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000 <BR/>2. Antibody dilution 1:1,000 + LIN7B immunizing peptide (human, 192-205)

Monoclonal Anti-LIN7B antibody produced in mouse - SAB4100086 from Sigma-Aldrich

Prices $358.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone LIN7B-B68
<B>Immunofluorescence</B><BR/>U87 cells were fixed and permeabilized with 4% Paraformaldehyde and 0.5% Triton X-100. Fixed cells were stained with Mouse Anti-LIN7B Clone: LIN7B-B68 (<B>Cat. No. SAB4100086</B>) diluted to 1:50. The antibody was developed using Goat Anti-Mouse IgG, Atto 488 conjugate. Cells were counterstained with DAPI (blue) to stain nuclei.

LIN7B-Antibody-N-term - AP19782a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
LIN7B Antibody (N-term) (Cat. #AP19782a) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the LIN7B antibody detected the LIN7B protein (arrow).

LIN7B--MALS-2-Antibody-N-Term - AF2389a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2389a (0.5 µg/ml) staining of Rat Brain lysate (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Search more