FOXA1

Gene Symbol	FOXA1
Entrez Gene	3169
Alt Symbol	HNF3A, TCF3A
Species	Human
Gene Type	protein-coding
Description	forkhead box A1
Other Description	HNF-3-alpha|HNF-3A|TCF-3A|forkhead box protein A1|hepatocyte nuclear factor 3-alpha|transcription factor 3A
Swissprots	B2R9H6 P55317 B7ZAP5 Q9H2A0
Accessions	AAD51979 AAG40847 EAW65844 P55317 AK304119 BAG65019 AK313785 BAG36523 AK316360 BAH14731 AM392863 CAL37741 AM393239 CAL38117 AM393310 CAL38188 AM393369 CAL38247 BC033890 AAH33890 BM970983 BU860564 DA705947 U39840 AAB06493 NM_004496 NP_004487
Function	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activit
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.
Tissue Specificity	Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas. {ECO:0000269|PubMed:12234996, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FOXA1 full length protein - ab98301 from Abcam Category Protein Source E. coli Species Human

Human FOXA1 peptide - ab25752 from Abcam Category Peptide

Human FOXA1 peptide - ab23074 from Abcam Category Peptide Species Human

FOXA1 Antibody Blocking Peptide - LS-E3590 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA1 Antibody Blocking Peptide - LS-E25558 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA1 Antibody Blocking Peptide - LS-E11458 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA1 Antibody Blocking Peptide - LS-E31408 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FOXA1 Antibody Blocking Peptide - LS-E13827 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FOXA1 Antibody Blocking Peptide - LS-E21157 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HNF-3 alpha/FoxA1 Protein - H00003169-P01 from Novus Biologicals Category Protein Prices $305.00, $445.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HNF-3 alpha/FoxA1 Protein - H00003169-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HNF-3 alpha/FoxA1 Protein - H00003169-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FOXA1-Antibody-Center-S286-Blocking-Peptide - BP14791c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOXA1 blocking peptide - GTX25089-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Pig, Rat, Bovine

FOXA1 Peptide - AC21-0387-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

FOXA1 / TCF3A - H00003169-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

FOXA1 / TCF3A - H00003169-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

FOXA1 / TCF3A - H00003169-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

FOXA1 / TCF3A - H00003169-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FOXA1 Peptide - 7255P from ProSci Category Peptide Species Human

FOXA1 Peptide - 45-599P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse

FOXA1 fusion protein - Ag14243 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

FOXA1 fusion protein - Ag14502 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human FOXA1 - FOXA1-28105TH from Creative Biomart Category Protein Source E. coli

Recombinant Human FOXA1, GST-tagged - FOXA1-12967H from Creative Biomart Category Protein Source E.coli Species Human

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