FOXA1

Gene Symbol	FOXA1
Entrez Gene	3169
Alt Symbol	HNF3A, TCF3A
Species	Human
Gene Type	protein-coding
Description	forkhead box A1
Other Description	HNF-3-alpha|HNF-3A|TCF-3A|forkhead box protein A1|hepatocyte nuclear factor 3-alpha|transcription factor 3A
Swissprots	B2R9H6 P55317 B7ZAP5 Q9H2A0
Accessions	AAD51979 AAG40847 EAW65844 P55317 AK304119 BAG65019 AK313785 BAG36523 AK316360 BAH14731 AM392863 CAL37741 AM393239 CAL38117 AM393310 CAL38188 AM393369 CAL38247 BC033890 AAH33890 BM970983 BU860564 DA705947 U39840 AAB06493 NM_004496 NP_004487
Function	Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activit
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.
Tissue Specificity	Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas. {ECO:0000269|PubMed:12234996, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:16331276}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HNF-3α CRISPR/Cas9 KO Plasmid (h) - sc-400743 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α HDR Plasmid (h) - sc-400743-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α Double Nickase Plasmid (h) - sc-400743-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α Double Nickase Plasmid (h2) - sc-400743-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α CRISPR Activation Plasmid (h) - sc-400743-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α CRISPR Activation Plasmid (h2) - sc-400743-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α Lentiviral Activation Particles (h) - sc-400743-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α Lentiviral Activation Particles (h2) - sc-400743-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α siRNA (h) - sc-37930 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HNF-3α shRNA Plasmid (h) - sc-37930-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HNF-3α shRNA (h) Lentiviral Particles - sc-37930-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

HNF-3 alpha/FoxA1 RNAi - H00003169-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

HNF-3 alpha/FoxA1 RNAi - H00003169-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU155811 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2227 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2227 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

FOXA1 siRNA (Human) - CRH2163 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

FOXA1 - MBS8214569 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

HNF-3α CRISPR/Cas9 KO Plasmid (h2) - sc-400743-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

HNF-3α HDR Plasmid (h2) - sc-400743-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human FOXA1 (NM_004496.3) - SHH296361 from Creative biogene Category siRNA Species Reactivities Human

FOXA1 shRNA Plasmid (Human) - CHH2163 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

FOXA1 miRNA 3'UTR clone - MiUTR3H-04851 from Creative biogene Species Reactivities Human

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