MAP3K8

Gene Symbol	MAP3K8
Entrez Gene	1326
Alt Symbol	AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 8
Other Description	Ewing sarcoma transformant|augmented in rheumatoid arthritis 2|cot (cancer Osaka thyroid) oncogene|proto-oncogene c-Cot|proto-oncogene serine/threoine protein kinase|tumor progression locus 2
Swissprots	D3DRX1 P41279 Q9HC81 Q14275 Q5T855 A8K2Q5
Accessions	AAP45053 EAW86004 EAW86005 EAW86006 EAW86007 P41279 AA156603 AB209539 BAD92776 AK290320 BAF83009 AK313295 BAG36102 AL547407 BC022398 BC104833 AAI04834 BC113566 AAI13567 BR000407 FAA00321 CR542284 CAG47079 D14497 BAA03387 DA308072 DB271664 HQ258255 ADR83009 Z14138 CAA78512 XM_005252364 XP_005252421 XM_011519308 XP_011517610 XM_011519309 XP_011517611 XM_011519310 XP_011517612 XM_011519311 XP_011517613 XM_011519312 XP_011517614 XM_011519313 XP_011517615 XM_011519314 XP_011517616 XM_011519315 XP_011517617 NM_001244134 NP_001231063 NM_005204 NP_005195
Function	Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B- cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a ro
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}.
Tissue Specificity	Expressed in several normal tissues and human tumor-derived cell lines.
Top Pathways	Toll-like receptor signaling pathway, T cell receptor signaling pathway, MAPK signaling pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-MAP3K8 / TPL2 (Thr290) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1081 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate

Mouse/Human/Rat MAP3K8 / TPL2 ELISA Kit (Cell-Based ELISA) - LS-F2127 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Lizard Estradiol ELISA kit - 55R-2110 from Fitzgerald Category ELISA Kit Prices $525.00 Sizes 96 tests

Tadpole Estradiol ELISA kit - 55R-2033 from Fitzgerald Category ELISA Kit Prices $475.00 Sizes 96 tests

MAP3K8 Colorimetric Cell-Based ELISA Kit - CB5426 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

MAP3K8 (Phospho-Thr290) Colorimetric Cell-Based ELISA Kit - CBP1057 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

mitogen-activated protein kinase kinase kinase 8, ELISA Kit - MBS9325582 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/ml. Range 3.12 ng/ml - 100 ng/ml.

MAP3K8 ELISA Kit - DEIA-XYA1164 from Creative Diagnostics Category ELISA Kit

MAP3K8 (Phospho-Thr290) ELISA Kit - DEIA-XYA1165 from Creative Diagnostics Category ELISA Kit

Human MAP3K8 ELISA Kit - E089008 from Biobool Category ELISA Kit

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388292 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388284 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388277 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388280 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388278 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388279 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388283 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388288 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388281 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388285 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388287 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388286 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388282 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388289 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mitogen Activated Protein Kinase Kinase Kinase 8 (MAPK8), ELISA Kit - MBS9388290 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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