MAP3K8

Gene Symbol	MAP3K8
Entrez Gene	1326
Alt Symbol	AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase kinase kinase 8
Other Description	Ewing sarcoma transformant|augmented in rheumatoid arthritis 2|cot (cancer Osaka thyroid) oncogene|proto-oncogene c-Cot|proto-oncogene serine/threoine protein kinase|tumor progression locus 2
Swissprots	D3DRX1 P41279 Q9HC81 Q14275 Q5T855 A8K2Q5
Accessions	AAP45053 EAW86004 EAW86005 EAW86006 EAW86007 P41279 AA156603 AB209539 BAD92776 AK290320 BAF83009 AK313295 BAG36102 AL547407 BC022398 BC104833 AAI04834 BC113566 AAI13567 BR000407 FAA00321 CR542284 CAG47079 D14497 BAA03387 DA308072 DB271664 HQ258255 ADR83009 Z14138 CAA78512 XM_005252364 XP_005252421 XM_011519308 XP_011517610 XM_011519309 XP_011517611 XM_011519310 XP_011517612 XM_011519311 XP_011517613 XM_011519312 XP_011517614 XM_011519313 XP_011517615 XM_011519314 XP_011517616 XM_011519315 XP_011517617 NM_001244134 NP_001231063 NM_005204 NP_005195
Function	Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B- cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a ro
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}.
Tissue Specificity	Expressed in several normal tissues and human tumor-derived cell lines.
Top Pathways	Toll-like receptor signaling pathway, T cell receptor signaling pathway, MAPK signaling pathway, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MAP3K8 protein fragment - ab55700 from Abcam Category Protein Prices $302.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

Active mouse MAP3K8 protein fragment - ab196418 from Abcam Category Protein Prices $359.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Mouse

Human MAP3K8 full length protein - ab132532 from Abcam Category Protein Source Wheat germ Species Human

Human MAP3K8 protein fragment - ab152292 from Abcam Category Protein Source Wheat germ Species Human

Human MAP3K8 protein fragment - ab84728 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

COT / CROT Antibody Blocking Peptide - LS-E27610 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COT / CROT Antibody Blocking Peptide - LS-E27611 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COT / CROT Antibody Blocking Peptide - LS-E17673 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

COT / CROT Antibody Blocking Peptide - LS-E10097 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP3K8 / TPL2 Antibody Blocking Peptide - LS-E10674 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP3K8 / TPL2 Antibody Blocking Peptide - LS-E7368 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP3K8 / TPL2 Antibody Blocking Peptide - LS-E9366 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP3K8 / TPL2 Antibody Blocking Peptide - LS-E9392 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAP3K8 / TPL2 Antibody Blocking Peptide - LS-E29197 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MAP3K8 / TPL2 Antibody Blocking Peptide - LS-E29211 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human MAP3K8/Tpl2/COT Protein - H00001326-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MAP3K8/Tpl2/COT Protein - H00001326-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MAP3K8/Tpl2/COT Recombinant Protein - P4671 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

MAP3K8/Tpl2/COT Peptide - NBP1-62180 from Novus Biologicals Category Peptide Prices $249.00 Sizes 250 µg

MAP3K8/Tpl2/COT Peptide - P1548 from Novus Biologicals Category Peptide Species Human

MAP3K8/Tpl2/COT Peptide - P2944 from Novus Biologicals Category Peptide Species Human

MAP3K8/Tpl2/COT Peptide - P2894 from Novus Biologicals Category Peptide Species Human

Phospho-MAP3K8T290-Antibody-Blocking-peptide - BP3413a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

COT-MAP3K8MEKK8-Antibody-C-term-Blocking-peptide - BP7957b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

COT-MAP3K8MEKK8-Antibody-C-term-Blocking-peptide - BP7913a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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