| Gene Symbol |
MAP3K8
|
| Entrez Gene |
1326
|
| Alt Symbol |
AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase kinase 8
|
| Other Description |
Ewing sarcoma transformant|augmented in rheumatoid arthritis 2|cot (cancer Osaka thyroid) oncogene|proto-oncogene c-Cot|proto-oncogene serine/threoine protein kinase|tumor progression locus 2
|
| Swissprots |
D3DRX1 P41279 Q9HC81 Q14275 Q5T855 A8K2Q5
|
| Accessions |
AAP45053 EAW86004 EAW86005 EAW86006 EAW86007 P41279 AA156603 AB209539 BAD92776 AK290320 BAF83009 AK313295 BAG36102 AL547407 BC022398 BC104833 AAI04834 BC113566 AAI13567 BR000407 FAA00321 CR542284 CAG47079 D14497 BAA03387 DA308072 DB271664 HQ258255 ADR83009 Z14138 CAA78512 XM_005252364 XP_005252421 XM_011519308 XP_011517610 XM_011519309 XP_011517611 XM_011519310 XP_011517612 XM_011519311 XP_011517613 XM_011519312 XP_011517614 XM_011519313 XP_011517615 XM_011519314 XP_011517616 XM_011519315 XP_011517617 NM_001244134 NP_001231063 NM_005204 NP_005195
|
| Function |
Required for lipopolysaccharide (LPS)-induced, TLR4- mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF- alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B- cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a ro
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}.
|
| Tissue Specificity |
Expressed in several normal tissues and human tumor-derived cell lines.
|
| Top Pathways |
Toll-like receptor signaling pathway, T cell receptor signaling pathway, MAPK signaling pathway, TNF signaling pathway
|