Gene Symbol | POC1B |
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Entrez Gene | 282809 |
Alt Symbol | CORD20, PIX1, TUWD12, WDR51B |
Species | Human |
Gene Type | protein-coding |
Description | POC1 centriolar protein B |
Other Description | POC1 centriolar protein homolog B|WD repeat-containing protein 51B|proteome of centriole protein 1B |
Swissprots | G3V1X0 Q8TC44 |
Accessions | BAB69430 CAF86799 CAF86800 EAW97425 EAW97426 EAW97427 Q8TC44 AB053266 BAB69057 AK027829 AK074772 BAC11198 AK123106 AK123625 BAC85666 AK295596 BAG58486 AL832918 CAH10775 AW149266 BC026080 AAH26080 BU521431 BX648293 DA851891 DC354425 EF011619 ABK41109 HQ447314 ADQ31801 NM_001199777 NP_001186706 NM_172240 NP_758440 NR_037659 NR_037660 |
Function | Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:20008567, ECO:0000269|PubMed:23015594, ECO:0000269|PubMed:25044745}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19109428, ECO:0000269|PubMed:23015594}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:20008567}. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles. Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. {ECO:0000250|UniProtKB:Q8BHD1}. |
Tissue Specificity | Expressed in the retina. {ECO:0000269|PubMed:25044745}. |
Human WDR51B full length protein - ab166110 from Abcam
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POC1B / WDR51B Antibody Blocking Peptide - LS-E671 from LifeSpan Bioscience
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POC1B / WDR51B Antibody Blocking Peptide - LS-E20106 from LifeSpan Bioscience
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Recombinant Human WDR51B Protein - H00282809-P01 from Novus Biologicals
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WDR51B-Antibody-C-term-Blocking-peptide - BP11016b from Abgent, a WuXi AppTec company
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WDR51B Blocking Peptide - 33R-3452 from Fitzgerald
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WDR51B - H00282809-P01-10 from Acris Antibodies
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WDR51B - H00282809-P01-25 from Acris Antibodies
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WDR51B fusion protein - ag20160 from Proteintech Group
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WDR51B fusion protein - ag20200 from Proteintech Group
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Recombinant Human POC1 centriolar protein homolog B(POC1B) - CSB-YP855046HU CSB-EP855046HU CSB-BP855046HU CSB-MP855046HU from Cusabio
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POC1B Protein - abx163430 from Abbexa
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WDR51B - TP305470 from Acris Antibodies
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POC1 centriolar protein homolog B (POC1B), Recombinant Protein - MBS1341006 from MyBioSource
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WDR51B Protein - NBP1-92584PEP from Novus Biologicals
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WDR51B-Blocking-Peptide-C-term - BP21756b from Abgent, a WuXi AppTec company
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POC1B Peptide, Human - M34GP12049H from Creative Peptides
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