TFF1
| Gene Symbol | TFF1 |
|---|---|
| Entrez Gene | 7031 |
| Alt Symbol | BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | trefoil factor 1 |
| Other Description | breast cancer estrogen-inducible protein|breast cancer estrogen-inducible sequence|gastrointestinal trefoil protein pS2|polypeptide P1.A|protein pS2 |
| Swissprots | P04155 |
| Accessions | BAA95532 BAB13729 CAA28695 EAX09569 P04155 BC032811 AAH32811 BQ083523 BU539534 M12075 AAA52402 X00474 CAA25155 X52003 CAA36254 NM_003225 NP_003216 |
| Function | Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine. {ECO:0000269|PubMed:16308573}. |
| Subcellular Location | Secreted {ECO:0000269|PubMed:15924415, ECO:0000269|PubMed:3041593}. |
| Tissue Specificity | Found in stomach, with highest levels in the upper gastric mucosal cells (at protein level). Detected in goblet cells of the small and large intestine and rectum, small submucosal glands in the esophagus, mucous acini of the sublingual gland, submucosal glands of the trachea, and epithelial cells lining the exocrine pancreatic ducts but not in the remainder of the pancreas (at protein level). Scattered expression is detected in the epithelial cells of the gallbladder and submucosal glands of the vagina, and weak expression is observed in the bronchial goblet cells of the pseudostratified epithelia in the respiratory system (at protein level). Detected in urine (at protein level). Strongly expressed in breast cancer but at low levels in normal mammary tissue. It is regulated by estrogen in MCF-7 cells. Strong expression found in normal gastric mucosa and in the regenerative tissues surrounding ulcerous lesions of gastrointestinal tract, but lower expression found in gastric cancer (at p |
pS2 CRISPR/Cas9 KO Plasmid (h) - sc-402867 from Santa Cruz Biotechnology
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pS2 HDR Plasmid (h) - sc-402867-HDR from Santa Cruz Biotechnology
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pS2 Double Nickase Plasmid (h) - sc-402867-NIC from Santa Cruz Biotechnology
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pS2 Double Nickase Plasmid (h2) - sc-402867-NIC-2 from Santa Cruz Biotechnology
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pS2 CRISPR Activation Plasmid (h) - sc-402867-ACT from Santa Cruz Biotechnology
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pS2 CRISPR Activation Plasmid (h2) - sc-402867-ACT-2 from Santa Cruz Biotechnology
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pS2 Lentiviral Activation Particles (h) - sc-402867-LAC from Santa Cruz Biotechnology
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pS2 Lentiviral Activation Particles (h2) - sc-402867-LAC-2 from Santa Cruz Biotechnology
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pS2 siRNA (h) - sc-39809 from Santa Cruz Biotechnology
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pS2 shRNA Plasmid (h) - sc-39809-SH from Santa Cruz Biotechnology
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pS2 shRNA (h) Lentiviral Particles - sc-39809-V from Santa Cruz Biotechnology
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TFF1/pS2 RNAi - H00007031-R01 from Novus Biologicals
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MISSION® esiRNA - EHU057351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21259 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21259 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00809 from Sigma-Aldrich
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TFF1 siRNA (Human) - CRH4805 from Cohesion Biosciences
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TFF1 - MBS8237773 from MyBioSource
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shRNA set against Human TFF1 (NM_003225.2) - SHH426216 from Creative biogene
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shRNA set against Human TFF1(NM_003225.2) - SHL067050 from Creative biogene
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Human TFF1 siRNA - orb265307 from Biorbyt
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TFF1 shRNA Plasmid (Human) - CHH4805 from Cohesion Biosciences
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TFF1 miRNA 3'UTR clone - MiUTR1H-10342 from Creative biogene
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