EGLN2

Gene Symbol	EGLN2
Entrez Gene	112398
Alt Symbol	EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1
Species	Human
Gene Type	protein-coding
Description	egl-9 family hypoxia-inducible factor 2
Other Description	HIF-prolyl hydroxylase 1|egl nine homolog 2|estrogen-induced tag 6|hypoxia-inducible factor prolyl hydroxylase 1|prolyl hydroxylase domain-containing protein 1
Swissprots	Q9BV14 Q8WWY4 Q96KS0 A8K5S0
Accessions	CAD58204 CAF02209 EAW57007 EAW57008 EAW57009 EAW57010 EAW57011 Q96KS0 AA994838 AJ310544 CAC42510 AK025396 AK026863 AK074408 AK098182 AK314741 BAG37282 AL133009 CAB61353 AL832506 AM393809 CAL38684 AY040565 AAK82943 BC001723 AAH01723 BC036051 AAH36051 BG719538 DA300182 DB049419 NM_053046 NP_444274 NM_080732 NP_542770 NM_017555
Function	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the c
Subcellular Location	Nucleus {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}.
Tissue Specificity	Expressed in adult and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in adult brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and cancerous mammary, ovarian and prostate epithelium. {ECO:0000269|PubMed:12163023}.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PHD1/prolyl hydroxylase full length protein - ab132272 from Abcam Category Protein Source Wheat germ Species Human

Human PHD1/prolyl hydroxylase peptide - ab91085 from Abcam Category Peptide

EGLN2 / PHD1 Antibody Blocking Peptide - LS-E4482 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EGLN2 / PHD1 Antibody Blocking Peptide - LS-E12226 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EGLN2 / PHD1 Antibody Blocking Peptide - LS-E12370 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EGLN2 / PHD1 Antibody Blocking Peptide - LS-E14429 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EGLN2 / PHD1 Antibody Blocking Peptide - LS-E14430 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EGLN2 / PHD1 Antibody Blocking Peptide - LS-E9732 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human EGLN2/PHD1 Protein - H00112398-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EGLN2-Antibody-N-term-Blocking-Peptide - BP16800a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EGLN2-Antibody-Center-Blocking-Peptide - BP8703c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human EGLN2 protein - orb244176 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

EGLN2 Blocking Peptide - 33R-1603 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EGLN2 Blocking Peptide - 33R-5815 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Egln2 Blocking Peptide - 33R-3128 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EGLN2 Blocking Peptide - 33R-8295 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

EGLN2 / PHD1 - H00112398-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

EGLN2 / PHD1 - H00112398-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

EGLN2 fusion protein - ag3616 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant human Egl nine homolog 2 - CSB-YP007482HU CSB-BP007482HU CSB-MP007482HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Egl nine homolog 2 - CSB-EP007482HU from Cusabio Category Protein Source E.coli Species Human

Recombinant Human Egl nine homolog 2(EGLN2) - CSB-YP856968HU CSB-EP856968HU CSB-BP856968HU CSB-MP856968HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Egl nine homolog 2 - RPC140465 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

EGLN2 / PHD1 (transcript variant 1) - TP306152 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

EGLN2 / PHD1 (N-term HIS tag, transcript variant 3) - TP760370 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

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