EGLN2

Gene Symbol	EGLN2
Entrez Gene	112398
Alt Symbol	EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1
Species	Human
Gene Type	protein-coding
Description	egl-9 family hypoxia-inducible factor 2
Other Description	HIF-prolyl hydroxylase 1|egl nine homolog 2|estrogen-induced tag 6|hypoxia-inducible factor prolyl hydroxylase 1|prolyl hydroxylase domain-containing protein 1
Swissprots	Q9BV14 Q8WWY4 Q96KS0 A8K5S0
Accessions	CAD58204 CAF02209 EAW57007 EAW57008 EAW57009 EAW57010 EAW57011 Q96KS0 AA994838 AJ310544 CAC42510 AK025396 AK026863 AK074408 AK098182 AK314741 BAG37282 AL133009 CAB61353 AL832506 AM393809 CAL38684 AY040565 AAK82943 BC001723 AAH01723 BC036051 AAH36051 BG719538 DA300182 DB049419 NM_053046 NP_444274 NM_080732 NP_542770 NM_017555
Function	Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the c
Subcellular Location	Nucleus {ECO:0000269|PubMed:12163023, ECO:0000269|PubMed:12615973, ECO:0000269|PubMed:19339211, ECO:0000269|PubMed:19631610}.
Tissue Specificity	Expressed in adult and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in adult brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and cancerous mammary, ovarian and prostate epithelium. {ECO:0000269|PubMed:12163023}.
Top Pathways	Renal cell carcinoma

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HIF PHD1 (A-16) - sc-46024 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HIF PHD1 (N-13) - sc-46025 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

HIF PHD1 (S-16) - sc-46026 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PHD1/prolyl hydroxylase antibody - ab127905 from Abcam Prices $384.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-PHD1/prolyl hydroxylase antibody - ab86980 from Abcam Prices $378.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PHD1/prolyl hydroxylase antibody - ab80361 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PHD1/prolyl hydroxylase antibody - ab93219 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PHD1/prolyl hydroxylase antibody [EPR2745] - ab108980 from Abcam Prices $388.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2745

Anti-PHD1/prolyl hydroxylase antibody [EPR2746] - ab113077 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR2746

Anti-PHD1/prolyl hydroxylase antibody [PHD112/G7] - ab82884 from Abcam Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone PHD112/G7

Anti-EGLN2 / PHD1 Antibody (C-Terminus, DY650) - LS-C142787 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (C-Terminus, Biotin) - LS-C142786 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (C-Terminus, DY488) - LS-C142788 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (C-Terminus, HRP) - LS-C142789 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (C-Terminus, DY550) - LS-C142790 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody - LS-C144104 from LifeSpan Bioscience Prices $605.00 Sizes 100 µg Host Sheep Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (C-Terminus) - LS-C49072 from LifeSpan Bioscience Prices $365.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (aa281-315) - LS-C101515 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (C-Terminus) - LS-C110437 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (clone PHD112/G7) - LS-C188433 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone PHD112/G7

Anti-EGLN2 / PHD1 Antibody (Internal, AP) - LS-C234881 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (Internal, APC) - LS-C234880 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (Internal, FITC) - LS-C234882 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (Internal, PE) - LS-C234883 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-EGLN2 / PHD1 Antibody (aa95-123, AP) - LS-C234884 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

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