| Gene Symbol |
KRTAP12-1
|
| Entrez Gene |
353332
|
| Alt Symbol |
KAP12.1, KRTAP12.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
keratin associated protein 12-1
|
| Other Description |
high sulfur keratin-associated protein 12.1|keratin-associated protein 12-1|keratin-associated protein 12.1
|
| Swissprots |
P59990 Q0VAS3
|
| Accessions |
EAX09405 P59990 AB076363 BAD01550 AJ566388 CAD97468 BC119713 AAI19714 BC120942 AAI20943 BC127648 AAI27649 NM_181686 NP_859014
|
| Function |
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.
|
| Tissue Specificity |
Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}.
|