Gene Symbol | KRTAP12-1 |
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Entrez Gene | 353332 |
Alt Symbol | KAP12.1, KRTAP12.1 |
Species | Human |
Gene Type | protein-coding |
Description | keratin associated protein 12-1 |
Other Description | high sulfur keratin-associated protein 12.1|keratin-associated protein 12-1|keratin-associated protein 12.1 |
Swissprots | P59990 Q0VAS3 |
Accessions | EAX09405 P59990 AB076363 BAD01550 AJ566388 CAD97468 BC119713 AAI19714 BC120942 AAI20943 BC127648 AAI27649 NM_181686 NP_859014 |
Function | In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins. |
Tissue Specificity | Restricted to a narrow region of the hair fiber cuticle, lying approximately 20 cell layers above the apex of the dermal papilla of the hair root; not detected in any other tissues. {ECO:0000269|PubMed:14962103, ECO:0000269|PubMed:15028290}. |
KRTAP12-1 CRISPR/Cas9 KO Plasmid (h) - sc-415673 from Santa Cruz Biotechnology
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KRTAP12-1 HDR Plasmid (h) - sc-415673-HDR from Santa Cruz Biotechnology
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KRTAP12-1 Double Nickase Plasmid (h) - sc-415673-NIC from Santa Cruz Biotechnology
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KRTAP12-1 Double Nickase Plasmid (h2) - sc-415673-NIC-2 from Santa Cruz Biotechnology
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KRTAP12-1 CRISPR Activation Plasmid (h) - sc-415673-ACT from Santa Cruz Biotechnology
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KRTAP12-1 CRISPR Activation Plasmid (h2) - sc-415673-ACT-2 from Santa Cruz Biotechnology
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KRTAP12-1 Lentiviral Activation Particles (h) - sc-415673-LAC from Santa Cruz Biotechnology
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KRTAP12-1 Lentiviral Activation Particles (h2) - sc-415673-LAC-2 from Santa Cruz Biotechnology
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KRTAP12-1 siRNA (h) - sc-91481 from Santa Cruz Biotechnology
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KRTAP12-1 shRNA Plasmid (h) - sc-91481-SH from Santa Cruz Biotechnology
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KRTAP12-1 shRNA (h) Lentiviral Particles - sc-91481-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN11428 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11428 from Sigma-Aldrich
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KRTAP12-1 siRNA (Human) - CRJ7586 from Cohesion Biosciences
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shRNA set against Human KRTAP12-1(NM_181686.1) - SHH138719 from Creative biogene
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Human KRTAP12-1 siRNA - orb278087 from Biorbyt
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KRTAP12-1 shRNA Plasmid (Human) - CHJ7586 from Cohesion Biosciences
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KRTAP12-1 miRNA 3'UTR clone - MiUTR1H-05487 from Creative biogene
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