| Gene Symbol |
NDUFA13
|
| Entrez Gene |
51079
|
| Alt Symbol |
B16.6, CDA016, CGI-39, GRIM-19, GRIM19
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
|
| Other Description |
CI-B16.6|NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13|NADH-ubiquinone oxidoreductase B16.6 subunit|cell death regulatory protein GRIM-19|cell death-regulatory protein GRIM19|complex I B16.6 subunit|complex I-B16.6|gene associated with retinoic and IFN-induced mortality 19 protein|gene associated with retinoic and interferon-induced mortality 19 protein
|
| Swissprots |
Q6PKI0 Q9Y327 Q9H2L3 Q9P0J0 K7EK58 B4DF76
|
| Accessions |
EAW84826 Q9P0J0 AF261134 AAG44670 AF286697 AAG28167 AK293859 BAG57254 BC000589 AAH00589 BC009189 AAH09189 BG705222 BG724220 BM839920 BP230223 DB450544 NM_015965 NP_057049
|
| Function |
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes. {ECO:0000269|PubMed:12628925, ECO:0000269|PubMed:12867595, ECO:0000269|PubMed:15753091}.
|
| Subcellular Location |
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side. Nucleus. Note=May be translocated into the nucleus upon IFN/RA treatment.
|
| Tissue Specificity |
Widely expressed, with highest expression in heart, skeletal muscle, liver, kidney and placenta. In intestinal mucosa, down-regulated in areas involved in Crohn disease and ulcerative colitis. {ECO:0000269|PubMed:10924506}.
|
| Top Pathways |
Alzheimer's disease, Huntington's disease, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation
|
![Western Blot: GRIM19 Overexpression Lysate (Adult Normal) [NBL1-13538] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GRIM19.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7881_GRIM19%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13538-img0002.jpg)